Title: Mucosal And Skin Reactions In Altered Fractionation Radiotherapy In Locally Advanced Oropharyngeal Carcinoma
Authors: Dr Murali. P, Dr Shankar Lal Jakhar, Dr Ramesh Purohit, Dr Rajesh Kumar, Dr Ajay Sharma
DOI: http://dx.doi.org/10.18535/jmscr/v4i5.46
INTRODUCTION: Mucositis and skin reactions are the most commonly encountered acute toxicities in head and neck irradiation. This is significantly higher in altered fractionation regimens. This study highlights the reactions in two different altered fractionation schedules of radiotherapy. AIM: to study the acute mucosal and skin reactions in altered fractionation radiotherapy in locally advanced oro-pharyngeal carcinoma. RESULTS: Among the ARM A and ARM B TNM-stage group at presentation was stage III: 40% and 52% and stage IV: 60 and 48 respectively. Grade III mucositis was encountered in 60% of patients in arm A compared to 32% in arm B (P=<0.01). Grade III skin reactions was seen more in arm A than arm B (52% Vs 24% ) (P=<0.01). CONCLUSION: In altered fractionation radiotherapy, it was found that early boosting has an edge over the late boosting in terms of manageable acute toxicities and better compliance.
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