Title: Performance of Urinary Liver Type Fatty Acid Binding Protein in Predicting Acute Kidney Injury in Post Cardiac Catheterization
Authors: Heba El-Shair, Rania Swelem, Sherif Wagdy
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.49
Acute kidney injury (AKI) is a common medical problem and is significantly associated with increasing morbidity and mortality. Contrast media (CM) is increasingly used in diagnostic and interventional procedures which results in the rising incidence of iatrogenic renal function impairment caused by the exposure to CM, a condition known as contrast induced nephropathy (CIN). The fatty acid-binding proteins (FABPs) are small cytoplasmic proteins abundantly expressed in tissues with active fatty acid metabolism. Nine distinct types have been identified, with each named after the tissue in which they were first identified.The urinary excretion of L-FABP reflects stress of proximal tubular epithelial cells, correlating with severity of ischemic tubular injury. The performance of urinary L-FABP as an early detection marker of AKI has shown promise in various clinical settings. We aim in this study to assess the feasibility of urinary L-FABP as very early marker of CI-AKI after cardiac catheterization in patient with stage 3or 4 CKD. A prospective study on 40 patients comparing urinary L-FABP excretion in group I (10 control subjects with normal renal functions) and group II (30 adult patients with chronic kidney disease stage 3or 4 and established AKI after elective cardiac catheterization at the Cardiology and Angilogy department. Measuring urinary L-FABP the day before and 6 hours after catheterization.There was a statistically significant positive correlation between u-LFABP/Cr0 and u-LFABP/Cr6 withCr0, Cr24, Cr48 ,Cr72. There was a statistically significant negative correlation between eGFR and u-LFABP. Keywords: U-LFABP,acute kidney injury, cardiac catheterization
Abstract
