Abstract
An acetone soluble leaf extract from Bauhinia variegata was investigated for its neuroprotective effects in the haloperidol induced catalepsy rat model of the disease by measuring behavioural and biochemical parameters in the model. In rat model catalepsy was induced by administration of haloperidol (1 mg/kg, p.o) in wistar rats of either sex. A significant reduction in the catalepsy was observed in the drug treated groups when compared to the disease induced group. The biochemical parameters were Lipid peroxidation, Glutathione (GSH) , Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were assessed in brain. Administration of haloperidol resulted in increased lipid peroxidation and decreased levels of antioxidant enzymes i.e GSH,GSH-Px and SOD. The study showed that the plant extract significantly decreased lipid peroxidation levels and increased antioxidant enzyme levels.
KEYWORDS: Bauhinia variegata, neuroprotective, antioxidant, antioxidant enzymes
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Corresponding Author
Vishakha Rajesh Trivedi
Dept of Pharmacology, Dr. L.H.Hiranandani College of Pharmacy
Ulhasnagar, Mumbai
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.47
