Abstract
Background: The present study was carried out for quantitative analysis of the mean MCC/optical field and MCD/sq. mm in the benign, premalignant and malignant oral lesions.
Objective: To analyse the role of mast cell in tumorogenesis.
Study Design: This study was carried out in the Department of Pathology, RNT Medical College, Udaipur. Punch biopsy of various oral lesions were selected. The sections were obtained and stained with Hematoxylin and Eosin and Toluidine blue. The number of mast cells/optical field and mast cell density/sq. mm were assessed. The following conclusions were drawn from our study.
Result: An increase in both mean MCC/optical field and MCD/sq. mm was found as the disease progress from benign to premalignant and to malignant oral lesions. This increase in the values was statistically significant between benign v/s malignant and premalignant v/s malignant. However value was found to be non-significant between benign v/s premalignant.
Keywords: Mast cells, Mast cell count, Mast cell density, Oral squamous cell carcinoma.
References
1. Mehrotra R, Singh M, Kumar D, Pande AN, Gupta R K, Sinha U S: Age specific incidence rate and pathological spectrum or oral cancer in Allahabad. Ind J Med Sci 2003; 57: 400-4.
2. Michailidou EZ, Markopoulos AK, Antoniades DZ: Mast cells and angiogenesis in oral malignant and premalignant lesions. The Open Dentistry Journal 2008; 2: 126-132.
3. Kinra M, Ramalingam K, Sarkar A, Rehman F, Girish KL: Comparison of mast cell count and mast cell density in normal mucosa, oral leukoplakia, oral lichen planus, oral submucos fibrosis and oral squamous cell carcinoma. Journal of Pharmaceutical and Scientific Innovation 2012; 1(2): 4-11.
4. Walsh LJ: Mast cells and oral inflammation. Crit. Rev. Oral Biol Med 2003; 14(3): 188-198.
5. Asboe-Hansen. The mast cells in health and disease. Acta Derm Venerol 1973; 53: 139.
6. Ehrlich P: Contributions to the Theory and Practice of Histological staining. Thesis, University of Leipzig, in 1878.
7. Lawrence B: Haemolymphoid system. In: Lawrence B, Martin BM, Patricia C, Mary D, Juhan D, editors. Gray's Anatomy. 38th ed. Edinburgh: Churchill Livingston Harcourt Publishers Ltd 2000; 1399-451.
8. Gurish MF, Austen KF: The diverse role of mast cells. J Exp Med 2001; 194: 1-5.
9. Galli SJ, Tsai M: Mast cells: Versatile regulators of inflammation, tissue remodeling, host defence and homeostasis. J Dermatol Sci 2008; 49: 7-19.
10. Conti P, Castellani ML, Kempuraj D: Role of mast cells in tumor growth. Ann Clin Lab Sci 2007; 37: 315-322.
11. Ribatti D, Vacca A, Dammacco F: The role of vascular phase in solid tumor growth: a historical review. Neoplasia 1999; 1: 293-302.
12. Norrby K: Mast cells and angiogenesis. APMIS 2002; 110: 355-71.
13. Iamaroon A, Pongsiriwet S, Jittidecharakas S, Pattanaporn K, Prapayasatok S, Wanachantararak S: Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma. J Oral Pathol Med 2003; 32: 195-9.
14. Sharma B, Sriram G, Saraswathi TR, Sivapathasundharam B: Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma. Indian J Dent Res 2010; 21: 260-5.
15. Anuradha A, Naik BK, Srinivas GV, Devi RS, Puneet HK. Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study. Journal of oncology 2014; 3.
16. Kalra M, Rao N, Nanda K, Rehman F, Girish KL, Tippu S, Arora A. The role of mast cells on angiogenesis in oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal 2012; 17(2): 190-6.
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.45
