Abstract
To evaluate the anti urolithiatic activity of Rhus mysorensis in experimentally induced urolithiasis in male wistar albino rats. The plant was shade dried at room temperature and coarsely powdered, extracted with 80% v/v alcohol. Male wistar albino rats were used for assessment of anti urolithiatic activity. Urolithiasis was induced in the animals using ethylene glycol and ammonium chloride. Standard drug cystone was used to treat standard group animals whereas ethanolic extract of Rhus mysorensis 200mg/kg b.w and 400mg/kg b.w were given to the test groups. Development of urolithiasis was confirmed by serum and urine biochemical estimations at the end of the experiment. Ethylene glycol and ammonium chloride developed calculi in the animals. Treatment with Rhus mysorensis reduced the formation of calculi. This was confirmed by biochemical estimations of urine and serum creatinine, calcium, oxalate, urea and uric acid. The mechanism underlying this effect is unknown but is apparently related to diuresis and lowering of urinary concentrations of stone forming agents. The protective effect against oxalate induced lipid peroxidation may be contributory to the recovery of renal damage. The present study revealed the anti urolithiatic activity of Rhus mysorensis against experimentally induced urolithiasis, reduced the formation of stones.
Keywords: Ammonium chloride, Calculi, Ethylene glycol, Rhus mysorensis, Urolithiasis,
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DOI: http://dx.doi.org/10.18535/jmscr/v3i9.40
