Abstract
The aims of this study was to investigated the role effect of Ultraviolet light on healing of liver injury in rats. fifteen adult healthy rats were used. It is divided in to two groups, treated group (Ultraviolet group) (9 rats), and control group (6 rats), for histopathological study 45 days post operation. The liver injury was done in the each rats after general anesthesia by scalpel. post-operation, in treated group, the rats were exposed to Ultraviolet light for 30 minute/daily (the rats exposed 5 days weekly) to period 45days continuously , but in control group, the rats leave without treated. In control group, the histopathological study of the prepared slides of the 45 day postoperative showed diffused enlargement of hepatocytes and congested of central vein and only minimal periportal fibrosis. In UV light group, the histopathological section showed the periportal fibrosis, also fibrosis around a portal artery. Minimal vacculation and enlargement of hepatocytes, also showed bile duct proliferation, diffuse enlargement of hepatocyte, septal fibrosis and mononuclear cells. Several areas of lobules with septal Fibrosis. Conclusion, the healing of the liver injury in treated group rapid from control group.
Keywords-Liver, Rat and Ultraviolet light.
References
M. Anthea, J. Hopkins, Ch. W. McLaughlin, S. Johnson, M. Q. Warner, D.LaHart and Wright J. D., Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1.OCLC 32308337. 1993.
D. Häussinger., Liver Regeneration. Berlin: De Gruyter ed.. p. 1. ISBN 9783110250794. 2011.
D.O. McDonagh., The Healing Power of Light Photoluminescence: UV Lght Irradiation inthe Laboratory. 1997.
S. Barnhart and E. Contributor, Medical Use of Ultraviolet Lights. 1997.
E. S. Thomas, M.D. ,P. Gonzalez, M.D and S. Cuccurullo, M.D., Modalities that use physical energy for their therapeutic effect. Physical Medicine and Rehabilitation Board Review.2004.
B.S. Maggie , A.A. Karl , E.R. Harvey and August , H.B., Effect of a short-term fast on Ketamine-Xylazine anesthesia in Rats. J Am assoc Lab Animals Sci. 50(3):344-348. 2011.
G. Ramadori , F. Moriconi , I. Malik and Dudas, J., Physiology and pathophysiology of liver inflammation damage and repair. Journal of Physiology and Pathophysiology, 59, suppl 1,107-117. 2008.
P. Chandra1, L. Linda., T. R. Ziegler1, J.Tian, M. Luo, A. A. Stecenko, T. C. Chen, M. F. Holick, and Vin T., Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series. 1Graduate Program in Nutrition and Health Sciences and Department of Medicine, Atlanta, GA,USA. Published in final edited form as: Photodermatol Photoimmunol Photomed. October ; 23(5): 179–185. doi:10.1111/j. 1600-0781.2007.00302.x. 2007.
M. T. Kitson, S. K. Roberts., D-livering the message: The importance of vitamin D status in chronic liver disease Department of Gastroenterology, The Alfred, Melbourne, Australia Journal of Hepatology vol. 57 j 897–909. 2012.
L. Lagoudakis, I. Garcin, B. Julien, K. Nahum, D. A. Gomes, L. Combettes, M. H. Nathanson, and Thierry T., Cytosolic Calcium Regulates Liver Regeneration in the Rat. Hepatology. August; 52(2): 602–611. doi:10.1002/hep. 23673. 2010.
S. Nair., Vitamin D Deficiency and Liver Disease. Gastroenterol Hepatol (N Y). Aug; 6(8): 491–493. 2010
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.23
