Abstract
An acetone soluble leaf extract from Bauhinia variegata was investigated for its neuroprotective effects in the reserpine induced catalepsy rat model of the disease by measuring behavioural and biochemical parameters in the model. In rat model catalepsy was induced by administration of reserpine (2.5 mg/kg, p.o) in wistar rats of either sex. A significant reduction in the catalepsy was observed in the drug treated groups when compared to the disease induced group. The biochemical parameters were Lipid peroxidation, Glutathione(GSH) , Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were assessed in brain. Administration of reserpine resulted in increased lipid peroxidation and decreased levels of antioxidant enzymes i.e GSH,GSH-Px and SOD. The study showed that the plant extract significantly decreased lipid peroxidation levels and increased antioxidant enzyme levels.
KEYWORDS: Bauhinia variegata, neuroprotective, antioxidant, antioxidant enzymes
References
Przedborski S, Vila M, Jackson-Lewis V. Neurodegeneration: What is it and where are we? The Journal of Clinical Investigation ,January 2003, Volume 111, Number 1.
Marshall R J. “The Overlooked Role of Chronic Infection in Neurodegeneration and Its Reversal Using Nutraceutical Agents”.
Rupavate S.(2014) Available at http://www.thehealthsite.com/diseases-conditions/world-parkinsons-day-2014-10-facts-about-parkinsons-disease/. Accessed on: 10 January 2015.
Wooten GF. Neurochemistry and neuropharmacology of Parkinson’s disease. In: Watts RL, Koller, editors. Movement disorders; Neurologic principles and practice. New York: McGraw Hill; 1997. p. 153-160.
Sahu G and Gupta PK. A review on Bauhinia variegata linn. International research Journal of pharmacy 2012;3(1):48-51.
Calderon J.L and Bolanos R, Behavioral Analysis of the Reserpine Induced Motor Changes in a Parkinsonian Mouse Model. Revista Neuropsicología, Neuropsiquiatría y Neurociencias, October 2011, Vol.11, Nº2, pp. 49-61.
Niehaus WG, Samuelson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem. 1968;6:126–130.
Rotruck JTAL, Pope HE and Ganther AB Swanson Biochemical role as acomponent of glutathione peroxidase. J science., 1973; 179: 588-590.
Bowling AC, Schulz JB, Brown RH, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993;61:2322-5.
Bafna P; Effect of aqueous extract of cynodondactylon on reserpine induced catalepsy; International Journal of Pharmacy and Pharmaceutical Sciences Vol 3, Issue 4, 2011.
Corresponding Author
Vishakha Trivedi
*Department of Pharmacology, Dr. L.H.Hiranandani College of Pharmacy
ULHASNAGAR, MUMBAI.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.19
