Clinical Evaluation of Sequential Application of Pulsed Dye Laser with 1064 Neodymium: Yttrium-Aluminum-Garnet Laser in the Treatment of Psoriasis

Title: Clinical Evaluation of Sequential Application of Pulsed Dye Laser with 1064 Neodymium: Yttrium-Aluminum-Garnet Laser in the Treatment of Psoriasis

Authors: Dr Hisham A. Shokeir, Dr Nevien A. Samy, Dr Maha R. Abo-Eittah, Dr Mohamed M. Soliman, Dr Noha G. Abdallah

DOI: http://dx.doi.org/10.18535/jmscr/v3i9.13

Abstract

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Abstract

Background: Angiogenesis has a crucial role in the pathogenesis and the maintenance of psoriasis. Dilated tortuous blood vessels can be acted upon by vascular lasers according to the principle of Anderson and Parrish.

Objective: The goal of this study was to evaluate the efficacy of the sequential application of pulsed dye laser (PDL) with Nd: YAG laser in the treatment of plaque psoriasis.

Design: This was a prospective clinical trial with a three-month follow-up.

Patients and Methods: Thirty three patients with chronic and stable plaque type psoriasis were included in this study. Patients received 7 sequential PDL + Nd: YAG laser treatments at two weeks intervals.

Intervention: Intervention included the application of seven sequential PDL and Nd: YAG laser treatments at two weeks intervals.

Outcome Assessment: Evaluation of clinical improvement by examination and photography.

Results: All patients showed a significant decrease in modified Psoriasis Area and Severity Index (m PASI) score.

Conclusion: Combined PDL + Nd: YAG presents a new therapeutic option for the treatment of plaque psoriasis.

Keywords: Angiogenesis, Cynosure, Nd: YAG, psoriasis vulgaris, Pulsed Dye Laser.

Abbreviations: L40: international classification of disease (ICD-10), Nd: YAG: Neodymium: Yttrium -Aluminum- Garnet, PDL: Pulsed Dye Laser, VEGFR; Vascular endothelial growth factor receptor.

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