Abstract
The present and future for cardiac biomarkers is exciting. In the near future, many of these biomarkers will provide important new insights into pathophysiology and aid in the diagnosis and management of cardiovascular patients. Hence from the above study it is found that appropriate study of cardiac markers like Total CPK, CPK-MB, LDH, SGOT, cTn-T, cTn-I is significant for the study and evaluation of myocardial infarction. Males are at higher risk than female for cardiac disease and also from my study it is found that cTn –Tis the reliable markers. Troponin-T is the best cardiac marker for detection of Myocardial Infarction (MI).Significant elevation of CK-MB activity as compared to AST and LDH proves as single enzyme criteria for the early markers of AMI. The extent of myocardial infarction can be made by the magnitude of elevated serum enzyme levels.
Keywords: Myocardial infarction, Tribals, Total CPK, CPK-MB.
References
- Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, et al. (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 108: 1664-1672.
- Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, et al. (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 338: 1650-1656.
- Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, et al. (2003) Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 290: 2277-2283.
- Arthur J Atkinson, Wayne A Colburn, Victor G DeGruttola, David L DeMets, Gregory J (2001) Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework*Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clinical Pharmacology & Therapeutics 69: 89-95.
- Sah AJ, Hoover DR (1997) “Sensitivity” and “specificity” reconsidered: the meaning of these terms in analytical and diagnostic settings. Ann Intern Med 126: 91-94.
- Dreyfus JC, Schapira G, Rasnais J, Scebat L (1960) Serum creatine kinase in the diagnosis of myocardial infarct. Rev Fr Etud ClinBiol 5: 386–387.
- Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, et al. (2007) ACC/ AHA 2007 guidelines for the management of patients with unstable angina/ non ST-elevation myocardial infarction: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines. Circulation 116: e148–304.
- Bassand JP, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernandez- Aviles F (2007) Guidelines for the diagnosis and treatment of non- ST-segment elevation acute coronary syndromes. Eur Heart J 28: 1598–1660.
- Thygesen K, Alpert JS, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction, Jaffe AS, Apple FS, et al. (2007) Universal definition of myocardial infarction. Circulation 116: 2634-2653.
- Morrow DA, Cannon CP, Rifai N, Frey MJ, Vicari R, et al. (2001) Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: results from a randomized trial. JAMA 286: 2405-2412.
- Yusuf S, Reddy S, Ounpuu S, et al. Global burden of cardiovascular diseases, I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104:2746 –2753.
- American Heart Association. 2002 Heart and Stroke Statistical Update. Dallas, Tex: American Heart Association; 2002.
- Myerburg RJ, Interian A Jr, Mitrani RM, et al. Frequency of sudden cardiacdeath and profiles of risk. Am J Cardiol. 1997; 80:10F–19F.
- Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334–2351.
- Ambrose JA, Tannenbaum MA, Alexopoulos D, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am CollCardiol. 1988; 12:56–62.
- Ahmad MI, Sharma N Biomarkers in Acute Myocardial Infarction. J Clin Exp Cardiolog 2012; 3:222.
Corresponding Author
Vineeta Chawla
PG Student Dept. of Biochemistry Pacific Medical College & Hospital Udaipur (Rajasthan), India
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.167
