Abstract
Introduction: Coronary heart disease (ischemic heart disease-IHD) is projected to be the leading cause of death by 2030, accounting for 25-30% of deaths in industrialized countries.
Aim and objective: To estimate serum Ischemia Modified albumin in myocardial ischemia patients and to correlate it with Ck-MB and lipid profile.
Materials and Methods: The present study was conducted to estimate serum Ischemia modified albumin by Albumin Cobalt Binding Assay in fifty subjects who were admitted in the Intensive Coronary Care Unit with complaints of chest pain of less than 6 hours duration along with ECG showing S-T,T changes. This was compared with fifty healthy subjects.
Results and Observation: Statistical analysis in the study group showed the mean value of Ischemia modified albumin as 88.52 Iu/ml and sensitivity of 78% which revealed a significant raise than Ck-MB [mean value of 56.50 U/Land sensitivity of 69%] during the early hours of ischemia. With an area under the curve of 0.921 and a standard error of 0.028, it also showed an asymptomatic significance of 0.001 proving it as a better predictor over Ck-MB in diagnosing myocardial ischemia.
Conclusion: Values obtained suggested a significant correlation between ischemia modified albumin and CK-MB,and also with age, total cholesterol and low density lipo protein. Analysis of Ischemia modified albumin helps to diagnose myocardial ischemia at an Earlier stage in the first 2-6 hours following an ischemic event before it progresses to irreversible myocardial cell damage and necrosis, unlike other previous laboratory parameters that identify myocardial damage only after it is well established
Keywords: IHD-ischemic heart disease, ACS-Acute coronary syndrome, IMA- ischemia modified albumin,
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DOI: http://dx.doi.org/10.18535/jmscr/v4i7.68
