Title: Platelet Volume Indices and Platelet Count in Patients with Acute Coronary Syndrome – Case control study
Author: Dr Shilpa N
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.02
Background: Myocardial infarction is major cause of morbidity and mortality. Platelets play causal role in acute coronary syndrome. An increase in mean platelet volume (MPV) and platelet distribution width (PDW) due to platelet activation is hypothesized in acute coronary syndromes. Aim: 1. To study platelet volume indices and platelet count in acute coronary syndrome. 2. To compare platelet volume indices and platelet count in acute coronary syndrome with age and sex matched controls. Materials: Present study is prospective case control study consisting of 200 subjects. Platelet count and platelet indices (MPV and PDW) are evaluated in two groups by automated cell analyser. First group consisted of patient with acute coronary syndrome and second group was age and sex matched controls. Statistical analysis: Data were analysed using SPSS software. Results were presented as mean, standard deviation. For the comparison of two groups, t test was applied. A p value of less than 0.05 was considered statistically significant. Results: There was a significant increase in MPV (p<0.01) and PDW (p<0.01) in patients with acute coronary syndrome compared to healthy control subjects. There was no statistical difference in platelet count among cases and controls (p=0.4). Conclusion: Platelet volume indices increase during platelet activation, as depicted by automated haematology analysers. Thus these are simple, reliable parameters, which can be used in routine practice to predict the impending adverse cardiac events. Keywords- Acute coronary syndromes, Mean platelet volume, Platelet distribution width, Platelet count.
Abstract
