A Study on Clinical Presentation and Outcome of Concurrent Malaria and Dengue Infection from a Malaria Endemic Zone of North India

Title: A Study on Clinical Presentation and Outcome of Concurrent Malaria and Dengue Infection from a Malaria Endemic Zone of North India

Authors: Rajendra Kumar Verma, Richa Giri, Nirmala Singh, Chirag Gupta, Arisht Jain

DOI: https://dx.doi.org/10.18535/jmscr/v4i12.132

Abstract

This study has been done to differentiate clinical and biological parameter of co-infections from infections alone and to find out whether patients infected by both malaria and dengue were more severe than either infection alone.

Material and Methods: All febrile adult patients (> 18 years of age) were investigated for malaria, dengue and other causes of fever. Patients of concurrent dengue and malaria (Group A) were compared with malaria mono-infection (Group B) and dengue mono-infection (Group C). Frequencies of alterations in clinical, biochemical, haematological parameters and outcome were determined in various groups. Data was analysed using appropriate statistical tests.

Results: Out of these 340 patients, there were 52 (15.29%), 132 (38.82%), and 156 (45.88%) patients in Groups A, B, and C respectively. Prevalence of co-infection in our study was 25%. Features like prolonged fever (7.18+/- 3.91), severe anemia (23.07%) and respiratory distress (7.69%) were comparable to malaria mono-infection whereas features like bleeding manifestations(15.38%), frontal or retro-orbital headache (80%), arthralgia (15.38%) and / elevated haematocrit were more like dengue mono-infection.

Conclusion: In endemic areas for dengue and malaria, prolonged fever, severe anemia and respiratory distress (in dengue patients) and bleeding manifestations, frontal or retro-orbital headache, arthralgia and / elevated haematocrit level (in malaria patients) should raise the suspicion of co-infection and since a high prevalence of co-infection was found in our geographical area. We recommend that all the patients suspected for dual infections should be treated concomitantly for dengue and malaria in malaria endemic areas.

Keywords: Malaria, Dengue, Co infection, India.

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Abstract

Call For Paper Volume 12 Issue 12 December 2024

JMSCR Menu

Impact Factor SJIF 2024: 7.892

Crossref - DOI

Editorial Policy

Frequency of Publication

Submission of Articles