Abstract

Background: Abnormality in liver function test parameters in patients with type 2 diabetes mellitus (T2DM) is common, but study comparing this association in patients of diabetes with or without hypertension is lacking.

Aims and Objective: To compare the liver function test parameters and its correlation with the lipids parameters in patients with T2DM and hypertension with diabetes.

Materials and Methods: A prospective study was done including 141 diabetic patients in the Department of Medicine, Mayo Institute of Medical sciences, Barabanki between February 2016 to June 2016. Patients were divided in to Group D (n=42, patients having diabetes) and Group HD (n=99, hypertensive diabetes mellitus). Patients were also divided on the basis of extend of glycemic control as good control (HbA1c <7%), poor control (HbA1c between 7-9%) and uncontrolled (HbA1c >9). Detailed demographic, glycemic, lipid and thyroid function test parameters were estimated in all the study population. Data collected was analysed using SPSS ver.20 and p value of <0.05 was considered as significant.

Results: Out of 141 patients, 42 (29.78%) were having diabetes alone, whereas 99 (70.21%) were having hypertension along with diabetes. All the demographic parameters except age (p=0.0003) were comparable. Glycemic parameters such as fasting plasma glucose (p>0.05) and post prandial blood glucose (p>0.05) were comparable except HbA1c (p=0.021) and average blood glucose (p=0.022) between both the groups. All the liver function test parameters including alkaline phosphatase, bilirubin direct, bilirubin total, bilirubin indirect, gamma-glutamyl transpeptidase (GGT), aspartate aminotransferase (SGOT) and alanine aminotransferase (SGPT) were insignificantly higher in patients with diabetes as compared to patients having diabetes with hypertension (p>0.05). However, bilirubin direct, GGT, SGOT and SGPT were higher than the normal range in patients with diabetes. Alkaline Phosphate, GGT, SGOT and SGPT were also significantly higher in patients with uncontrolled diabetes as compared to patients with good control (p<0.05).

Conclusion: Liver function test parameters such as bilirubin direct, GGT, SGOT and SGPT were higher in patients with T2DM, but comparable with patients with hypertensive diabetics. (p>0.05). Alkaline Phosphate, GGT, SGOT and SGPT were higher in patients with uncontrolled diabetes.

Keywords: liver function test, T2DM, hypertension