Background: The prognostic significance of albuminuria in perforation peritonitis is significant. In this study we assess relation between presence of albumin in urine and post operative mortality in perforation peritonitis.

Method-Our prospective observational study was conducted at Department of General Surgery, R.K.D.F. Medical College& Research Centre, Bhopal, during period of August 2013 to May 2015.Total 110 cases of perforation peritonitis were included. Urine albumin was measured in all patients diagnosed as perforation peritonitis at the time of admission and during hospital stay. Presence of albumin in urine was recognized as albuminuria. Site of perforation, Type of surgery, post operative complications, mortality and the association between presence of albumin in urine and post operative mortality in perforation peritonitis was assessed and evaluated.

Result- In this study of 110 patients, albumin in urine was present in 74 (67.27%) patient and was absent in 36 (32.72%) patients. Out of 74 patients with albuminuria, 20 (27%) patients died and remaining 36 patients without albuminuria 3(8.3%) had died. In present study, significant (p value<0.05) association was found among albuminuria and mortality in post operative peritonitis.

So it may be concluded that albuminuria can be used as poor prognostic factor for assessing post operative mortality in perforation peritonitis.

Conclusion- Albuminuria is a significant risk factor in assessing post operative mortality in perforation peritonitis.

Keywords-Albumin, Albuminuria, Perforation peritonitis, Mortality, Septicaemia

1.      Ramakrishnan K, Salinas RC. Peptic Ulcer disease. Am Fam Physician. 2007;1:1005–12. 

2.      Sharma L, Gupta S, Soin AS, Sikora S, Kapoor V. Generalized peritonitis in India. The Tropical Spectrum. Jpn J Surg. 1991;21:27277. doi: 10.1007/BF02470946.

3.      Ersumo T, W/MESKEL y, Kotisso B. Perforated peptic ulcer in TikurAnbessa Hospital; a review of 74 cases. Ethiop Med J. 2005;43:9–13. 

4.      Bosscha K, van Vroonhoven TJ, Werken C van der. Surgical management of severe secondary peritonitis. Br J Surg. 1999;86:1371–7. doi: 10.1046/j.1365-2168.1999.01258.x. 

5.      Uccheddu A, Floris G, Altana ML, Pisanu A, Cois A, Farci SL. Surgery for perforated peptic ulcer in the elderly. Evaluation offactors influencing prognosis hepatogastroenterology. 2003;50:19568. 

6.      Norman s Williams, Christopher JK, Bulstrode, P ronanan OConnell.Bailey & Love’s, Short Practice of surgery 26e(CRC Press book 2008) 8-16.

7.      Gibbs J, Cull W, Henderson W. Preoperative serum albumin level as a predictor of operative mortality and morbidity: results from the National VA Surgical Risk Study. Arch Surg. 1999;134:36-42.

8.      Peralta R. Hypoalbuminemia. Medscape Updated Clinical Reference. 2010.http://-emedicine.medscape.com/article/166724.