Abstract
Subjective: Many studies shown a relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes)
Aim of the study: This systemic article review aims to revise the main researches related to this subject and find out whether there is a significant relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes)
Methods: About 10retrospective and prospective (cohort) cross sectional related studies have been reviewed and analyzed for the purpose of reaching the results. High plasma homocysteine level (> 12μg/L), low serum vitamin B 12 level (< 200 μg/L)And low serum of vitamin B9(>140 μg/L)
Discussion: Multiple medical and nutritional studies talk, discuss, and explain the relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes)
Results: Most of the reviewed related researches have shown mild (weak) relationship between high plasma homocysteine level, low serum vitamin B12 and folate level, but this related researchhas shown mild significant relationship between high plasma homocysteine level, low serum vitamin B12 and folate and the increasing risk of incidental hip fracture.
Keywords: Osteoporosis, Vitamin B12, Homocysteine, Folic Acid, Hip Fracture.
References
- Papadakis, M. A., McPhee, S. J., Rabow, M. W. (2020). CURRENT Medical Diagnosis and Treatment 2021. United States: McGraw Hill LLC.
- Fratoni V, Brandi ML. B vitamins, homocysteine and bone health. Nutrients. 2015 Mar 30;7(4):2176-92. doi: 10.3390/nu7042176. PMID: 25830943; PMCID: PMC4425139.
- McLean RR, Jacques PF, Selhub J, Fredman L, Tucker KL, Samelson EJ, Kiel DP, Cupples LA, Hannan MT. Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab. 2008 Jun;93(6):2206-12. doi: 10.1210/jc.2007-2710. Epub 2008 Mar 25. PMID: 18364381; PMCID: PMC2435634.
- McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004 May 13;350(20):2042-9. doi: 10.1056/NEJMoa032739. PMID: 15141042.
- van Wijngaarden JP, Doets EL, Szczecińska A, Souverein OW, Duffy ME, Dullemeijer C, Cavelaars AE, Pietruszka B, Van't Veer P, Brzozowska A, Dhonukshe-Rutten RA, de Groot CP. Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses. J NutrMetab. 2013;2013:486186. doi: 10.1155/2013/486186. Epub 2013 Feb 20. PMID: 23509616; PMCID: PMC3590816.
- Ravaglia, P. Forti, F. Maioli et al., “Folate, but not homocysteine, predicts the risk of fracture in elderly persons,” Journals of Gerontology A, vol. 60, no. 11, pp. 1458–1462, 2005.
- Lips and N. M. van Schoor, “The effect of vitamin D on bone and osteoporosis,” Best Practice & Research, vol. 25, no. 4, pp. 585–591, 2011.
- Baines, M. B. Kredan, A. Davison et al., “The association between cysteine, bone turnover, and low bone mass,” Calcified Tissue International, vol. 81, no. 6, pp. 450–454, 2007.
- Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, et al. Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 2000;66:190–4.
- Bode MK, Laitinen P, Risteli J, Uusimaa P, Juvonen T. Atherosclerosis, type 1 collagen cross-linking and homocysteine. Atherosclerosis 2000;152:531–2.
- McLean M, McGowan TS, Catton CN, Catton PA, Panzarella T. The impact of prostatic manipulation upon serum PSA in patients with adenocarcinoma of the prostate. Clin Oncol (R Coll Radiol) 1993;5:293–6.
- Cummings SR, Bates D, Black DM. Clinical use of bone densitometry: scientific review. J Am Med Assoc 2002; 288:1889–97.
- Kanis JA, Black D, Cooper C, DargentP, Dawson-Hughes B, De Laet C, et al. A new approach to the development of assessment guidelines for osteoporosis. Osteoporos Int 2002;13:527–36
- Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, Volpe A. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008; 42(2):314-20.
- Rejnmark L, Vestergaard P, Hermann AP, Brot C, Eiken P, Mosekilde L. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women. Calcif Tissue Int. 2008; 82(1):1-11.
- Haliloglu B, Aksungar FB, Ilter E, Peker H, Akin FT, Mutlu N, et al. Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet. 2010; 281(4):663-8.
- Dai Z, Wang R, Ang LW, Yuan JM, Koh WP. Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study. Osteoporos Int. 2013; 24(7):2049-59
- Herrmann M, Umanskaya N, Wildemann B, Colaianni G, Widmann T, Zallone A, et al. Stimulation of osteoblast activity by homocysteine. J Cell Mol Med 2007. In press.
- Kim DJ, Koh JM, Lee O, Kim NJ, Lee YS, Kim YS, et al. Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 2006;39:582–90.
- Sakamoto W, Isomura H, Fujie K, Deyama Y, Kato A, Nishihira J, et al. Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3- E1 preosteoblastic cells. Biochim Biophys Acta 2005; 1740:12–6.
- Carmel R, Lau KH, Baylink DJ, Saxena S, Singer FR. Cobalamin and osteoblast-specific proteins. N Engl J Med 1988;319:70–5.
- Oxlund H, Barckman M, Ortoft G, Andreassen TT. Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone 1995;17: 365–71S.
- Oxlund H, Mosekilde L, Ortoft G. Reduced concentration of collagen reducible cross links in human trabecular bone with respect to age and osteoporosis. Bone 1996;19:479–84.
- Banse X, Sims TJ, Bailey AJ. Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links. J Bone Miner Res 2002; 17:1621–8.
- Banse X, Devogelaer JP, Lafosse A, Sims TJ, Grynpas M, Bailey AJ. Cross-link profile of bone collagen correlates with structural organization of trabeculae. Bone 2002;31:70–6.
- McKusick VA. Heritable disorders of connective tissue. St. Louis, MO: Mosby CV, 1966:155 pp.
Corresponding Author
Dr. Abdeljawad Salim Ayesh Salem
Consultant Family Medicine, South Wakra Health Center, Department of Primary Healthcare (PHCC), Ministry of Public Health (MOPH), Al wakra city. Qatar.
DOI: https://dx.doi.org/10.18535/jmscr/v11i9.09
