Abstract
Background: Hepatitis A is the most common infectious etiology of acute viral hepatitis. There has been an increase in incidence of disease in many parts of the world, along with more complications and many unwanted secondary effects. The main aim of study is to identify the clinical profile, unwanted secondary effects and risk factors associated with worst outcome.
Material and Methods: A Prospective observational study was conducted on 100 consecutive patients who attended the Civil Hospital, Gurdaspur, Punjab. The patients were kept under follow up for four months. Clinical evaluations and relevant investigations were conducted on those patients.
Results: Most of the patients were between 18 to 40 years. Thrombocytopenia, transverse myelitis, Loss of appetite, arthralgias , pancreatitis and acute renal injury were some of the unwanted secondary effects. Three patients died.
Conclusions: There were no correlation between SGPT levels and complications. Prior NSAID, Chemicals & alcohol intake is associated with adverse outcome.
Keywords: Acute Viral Hepatitis A, NSAIDS, Hepatic encephalopathy.
References
- Feinstone SM, Kapikian AZ, Purceli RH. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science 1973; 182:1026.
- Schiff ER. Atypical clinical manifestations of hepatitis A. Vaccine 1992; 10 Suppl 1:S18.
- Gust ID. Epidemiological patterns of hepatitis A in different parts of the world. Vaccine 1992; 10: 856-862.
- Tong MJ, el-Farra NS, Grew MI. Clinical manifestations of hepatitis A: recent experience in a community teaching hospital. J Infect Dis 1995; 171 Suppl 1:S15.
- Shenoy R, Nair S, Kamath N. Thrombocytopenia in hepatitis A--an atypical presentation. J Trop Pediatr 2004; 50:241.
- Rezende G, Roque-Alsonso M, Samuel D, et al: Viral and clinical factors associated with fulminant course of hepatitis A infection. Hepatology 2003; 38:613-18.
- Koff RS. Clinical manifestations and diagnosis of hepatitis A virus infection. Vaccine 1992; 10 Suppl 1:S15.
- Shouval D, Ashur Y, Adler R, et al. Safety, tolerability, and immunogenicity of an inactivated hepatitis A vaccine: effects of single and booster injections, and comparison to administration of immune globulin. J Hepatol 1993; 18 Suppl 2:S32.
- Kwon, So Young et al. “Clinical Characteristics and Outcomes of Acute Hepatitis A in Korea: A Nationwide Multicenter Study.” Journal of Korean Medical Science 2 (2014): 248–253.
- Jung YM, Park SJ, Kim JS, Jang JH, Lee SH, Kim JW, Park YM, Hwang SG, Rim KS, Kang SK, Lee HS, Yun HS, Jee YM, Jeong SH. Atypical manifestations of hepatitis A infection: a prospective, multicenter study in Korea. J Med Virol. 2010.
- Hadler SC, Webster HM, Erben JJ, Swanson JE, Maynard JE. Hepatitis A in day-care centers: a community-wide assessment. N Engl J Med 1980; 302: 1222-7.
- Sohn YM, Rho HO, Park MS, Park JH, Choi BY, Ki M, Jang WI. The chang¬ing epidemiology of hepatitis A in children and the consideration of active immunization in Korea. Yonsei Med J 2000; 41: 34-9.
Corresponding Author
Dr Maninderpal Singh Dhaliwal
Resident, Dept of General Medicine, M.G.M Medical College & L.S.K Hospital, Kishangang, Bihar
DOI: https://dx.doi.org/10.18535/jmscr/v11i3.26
