Abstract
Background: GIST (Gastrointestinal stromal tumours) are rare mesenchymal tumours of the Gastrointestinal tract accounting for 3% of Gastrointestinal malignancies and overexpress C-kit proteins CD117, CD34 and PGDFRA.
Methods: This clinical study was done on 32 patients of GIST in our institution over a period of 7 years with a minimum follow up of 5 years to study the demographics, presentation, management and prognostic criteria of GISTs.
Results: The majority of the tumours originated from stomach and small bowel, a few from Esophagus, Rectum and mesentery. GIST predominantly affected the elderly. CT scan and endoscopy were the main diagnostic modalities with final confirmation by Histopathology and immunohistochemistry. Most of the patients underwent surgical resection followed by oral imatinib.
Conclusion: GIST have unpredictable behavior. The malignant potential of the disease depends on the site, size and mitotic index of the tumour. Surgery with imatinib is the main treatment option in absence of response of GIST to Radio or chemotherapy.
Keywords: Gastrointestinal stromal tumours, Imatinibmesylate, enbloc resection.
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Corresponding Author
Dr Anant S. Ramani
Associate Professor of Surgery, Dept. of Surgery, Goa Medical College, Bambolim - Goa, Pin: 403502
DOI: https://dx.doi.org/10.18535/jmscr/v11i3.15
