Abstract
Spontaneous Intracranial hypotension is an uncommon benign condition that occurs due to cerebrospinal fluid leakage leading to low CSF pressures. Orthostatic headache is the most common distressing symptom. The aim of treating spontaneous intracranial hypotension (SIH) is to stop the CSF leak. SIH needs to be addressed in a timely manner, as the symptoms are disturbing, and also because the most common complication is subdural hematoma which could be potentially life threatening.
Materials and Method: We reviewed 12 cases from August 2015 to August 2021 of SIH in our institute. All cases were conducted by lumbar interlaminar approach, under fluoroscopic guidance. Results were shown as numbers (n) and percentage (%).
Epidural space was detected with loss of resistance technique in lateral position in L3-L4 space with a 16 gauge Tuohy needle, and a catheter introduced cranially as high as possible, but not necessarily at the leak site. 2cc Iohexol dye with 5 cc saline was then injected and epidural placement of catheter and spread of dye was confirmed. Thereafter, 15 cc of venous blood was withdrawn and injected immediately under fluoroscopic guidance. Catheter was then withdrawn and the head-low position given for at least thirty minutes. The patient was then shifted to the ward with instructions for strict bed rest for 24 hours.
Observation: All cases had a single successful epidural puncture attempt. No adverse hemodynamic events occurred. No Motor block of lower limbs or worsening of headache occurred.
Results: 83.33% had satisfactory relief of headache. 8.33% required surgery for repair of leak, this was observed in the post lumbar laminectomy patient, while 8.33% required repeat of epidural blood 3 times within a span of 3 months due to no significant relief of headache.
Conclusion: The interlaminar approach under local anesthesia for EBP is an easy and effective treatment modality for SIH for relief of pain.
The epidural blood patch seals the CSF leak, thereby improving the pressure and causing relief of symptoms. An epidural blood patch can be repeated if symptoms are not relieved as the complication rate is very low.
Keywords: epidural blood patch, spontaneous intracranial hypotension.
References
- Gordon N. Spontaneous intracranial hypotension. Dev Med Child Neurol. 2009 Dec;51(12):932-5. doi: 10.1111/j.1469-8749.2009.03514.x. PMID: 19909307.
- Schievink WI. Spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension. JAMA. 2006 May 17;295 (19):2286-96. doi: 10.1001/jama.295.19.2286. PMID: 16705110.
- Ferrante E, Rubino GF, Passarani S, Arpino I. Spontaneous intracranial hypotension. J Neurosurg. 2010 Aug;113(2):397-8; author reply 398-9. doi: 10.3171/2010.3.JNS10437. PMID: 20540597.
- Schievink, Wouter I. " Spontaneous spinal cerebrospinal fluid leaks: a review", Neurosurgical Focus FOC 9, 1 (2000): 1-9, accessed Dec 20, 2021, https://doi.org/10.3171/foc.2000.9.1.8
- Loya JJ, Mindea SA, Yu H, Venkatasubramanian C, Chang SD, Burns TC. Intracranial hypotension producing reversible coma: a systematic review, including three new cases. J Neurosurg. 2012 Sep;117(3):615-28. doi: 10.3171/2012.4.JNS112030. Epub 2012 Jun 22. PMID: 22725982.
- Zhang J, Jin D, Pan KH. Epidural blood patch for spontaneous intracranial hypotension with chronic subdural haematoma: A case report and literature review. J Int Med Res. 2016 Aug;44(4):976-81. doi: 10.1177/0300060516645955. Epub 2016 May 25. PMID: 27225863; PMCID: PMC5536624.
- Rando TA, Fishman RA. Spontaneous intracranial hypotension: report of two cases and review of the literature. Neurology. 1992 Mar;42(3 Pt 1):481-7. doi: 10.1212/wnl.42.3.481. PMID: 1549206.
- Schievink WI, Maya MM, Louy C, Moser FG, Tourje J. Diagnostic criteria for spontaneous spinal CSF leaks and intracranial hypotension. AJNR Am J Neuroradiol. 2008 May;29(5):853-6. doi: 10.3174/ajnr.A0956. Epub 2008 Feb 7. PMID: 18258706; PMCID: PMC8128584.
- Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013 Jul;33(9):629-808. doi: 10.1177/0333102413485658. PMID: 23771276.
- Schievink WI, Dodick DW, Mokri B, Silberstein S, Bousser MG, Goadsby PJ. Diagnostic criteria for headache due to spontaneous intracranial hypotension: a perspective. Headache. 2011 Oct;51(9):1442-4. doi: 10.1111/j.1526-4610.2011.01911.x. Epub 2011 Jun 9. PMID: 21658029.
- Thomas DL, Menda Y, Graham MM. Radionuclide cisternography in detecting cerebrospinal fluid leak in spontaneous intracranial hypotension: a series of four case reports. Clin Nucl Med. 2009 Jul;34(7):410-6. doi: 10.1097/RLU.0b013e3181a7d118. PMID: 19542942.
- Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology. 2001 Jun 26;56(12):1746-8. doi: 10.1212/wnl.56.12.1746. PMID: 11425944.
- Inamasu J, Nakatsukasa M. Blood patch for spontaneous intracranial hypotension caused by cerebrospinal fluid leak at C1-2. Clin Neurol Neurosurg. 2007 Oct;109 (8):716-9. doi: 10.1016/j.clineuro.2007.05.006. Epub 2007 Jun 15. PMID: 17573187.
- Rozec B, Guillon B, Desal H, Blanloeil Y. Intérêt du blood-patch pour le traitement de l'hypotension intracrânienne spontanée [Value of epidural blood-patches for the treatment of spontaneous intracranial hypotension]. Ann Fr Anesth Reanim. 2004 Dec;23(12):1144-8. French. doi: 10.1016/j.annfar.2004.09.009. PMID: 15589353.
- Pagani-Estévez GL, Cutsforth-Gregory JK, Morris JM, Mokri B, Piepgras DG, Mauck WD, Eldrige JS, Watson JC. Procedural predictors of epidural blood patch efficacy in spontaneous intracranial hypotension. Reg Anesth Pain Med. 2019 Jan 13:rapm-2018-000021. doi: 10.1136/rapm-2018-000021. Epub ahead of print. PMID: 30636714.
- https://www.csfleak.info/leakweek2018/dayfive/
Corresponding Author
Dr Dipti Madan
Bombay Hospital Institute of Medical Sciences, New Marine Lines, Mumbai 400020