Abstract
Background: Alpha 2 agonists are being used as adjuvants in epidural analgesia as they lead to analgesia, anxiolysis and sedation.
Aim: This study aims to evaluate the post operative analgesic effects of epidural dexmedetomidine and clonidine with 0.125%levobupivacaine
Methods: A comparative study was done to assess the efficacy and clinical profile of two α2 adrenergic agonists – clonidine and dexmedetomidine administered epidurally in combination with intrathecal 0.125%levobupivacaine. The study was conducted for 1 year. Sixty adult patients ASA-PS Class I and II undergoing pelvis and lower limb orthopaedic surgery were randomly assigned into two groups, to receive either epidural dexmedetomidine (1μg/kg) or clonidine (2 μg/kg) with 0.125% isobaric levobupivacaine.
Results: Dexmedetomidine provided a prolonged analgesia, as evidenced by the distribution of VAS scores and requirement rescue analgesic among two groups.
Keywords: Epidural analgesia, 0.125%Levobupivacaine, Dexmedetomidine, Clonidine.
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Corresponding Author
Dr Amutha Rani R MD
Prof & HOD, Department of Anaesthesiology, Tirunelveli Medical College
DOI: https://dx.doi.org/10.18535/jmscr/v10i2.31
