Title: Investigating the Biochemical Parameters Derangement and Physical Examination Findings in Patients with Non-Alcoholic Fatty Liver Disease
Authors: Dr Atul Shende, Dr Vinay Warkade, Dr Nischal Modak
DOI: https://dx.doi.org/10.18535/jmscr/v8i7.36
Abstract
Background: Fatty liver disease in the absence of alcohol abuse is now emerging as a major health burden in the world. Alteration in various biochemical parameters and obesity directly or indirectly affect NAFLD and may worsen its outcome thus the current study was planned.
Methods: This prospective observational study was conducted in 65 patients with ultrasonographic finding of fatty liver disease were selected either on OPD or IPD of Department of Medicine, MY Hospital, Indore.
Results: A total 65 patients were included. In our study most of the patients (33%) were of the age group 41-50 years. 45 patients are obese constituting 69% of total cases. Cholesterol has a negative correlation with waist hip ratio which is statistically significant (p=0.003) and has positive correlation with triglycerides which is statistically significant (p=0.000). Various biochemical parameters of the patients were compared across the gender where it was found that variable like triglycerides, ALT, AST, HOMA-IR, and adiponectin were approximately same across the gender without any significance but cholesterol values across the gender was significant (p=0.000).
Conclusions: HOMA-IR and adiponectin levels have no significant correlation with studied biochemical parameters, high BMI, and high waist circumference patients. Further studies in large number of cases are advised to include or exclude these findings.
Keywords: Adiponectin, Cholesterol, HOMA IR, triglycerides.
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