Abstract
Erectile Dysfunction (ED) is a common sexual problem, the prevalence increasing with age; severe ED seen in 5% of men at 40, tripling to 15% in men at 70 years of age. The prevalence rates of ED in young men in 20-40 years age group varies from 1.7% to 13% in various studies. Low testosterone is a well known but uncommon cause of ED.
This study aims at identifying hypogonadism in young men with ED. This is a retrospective clinic based study from South India done on young men of 20-40 years. One group of 142 men with Premature Ejaculation (PME), no ED; and another group of 269 men with ED with or without PME, demographically similar, attended the clinic during the same time were compared.
3% of men in PME group and 17% of men in ED group had total testosterone less than 240 ng/dl. 22% of men in PME group and 49% of men in ED group had total testosterone less than 360 ng/dl. The mean Total Testosterone (TT) value in PME group was 520 and the mean TT in ED group was 406.ng/dl. All of these are statistically significant. Hence it can be inferred that, even in young men, testosterone deficiency is not a rare cause, but a significant cause of ED.
Keywords: Erectile Dysfunction; Testosterone: Hypogonadism
References
- Feldman HA et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol 1994; 151: 54–61.
- Sathyanarayana Rao T S, Darshan M S, Tandon A. An epidemiological study of sexual disorders in south Indian rural population. Indian J Psychiatry 2015; 57:150-7
- Journal of Adolescent Health, Volume 51, Issue 1, 25 - 31
- J Urol 2004;Tl:525-529
- Int J Impot Res 1993; 5:97-103
- Benkert O, Witt W, Adam W, Leitz A. Effects of testosterone undecanoate on sexual potency and the hypothalamic-pituitary-gonadal axis of impotent males. Arch Sex Behav. 1979;8:471-480.
- Testosterone supplementation for hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes. J Urol. 1997;157:849854.
- Buena F, Swerdloff R, Steiner BS, et al. Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range. FertilSteril. 1993;59: 1118-1123.
- Morgentaler A, Traish A, Hackett G, et al. Diagnosis and Treatment of Testosterone Deficiency: Updated Recommendations From the Lisbon 2018 International Consultation for Sexual Medicine. Sex Med Rev 2019;7:636–649.
- Urol Int 2014;92:1–6 DOI: 10.1159/000354931
- Liao M, Huang X, Gao Y, Tan A, Lu Z, et al. (2012) Testosterone Is Associated with Erectile Dysfunction: A Cross-Sectional Study in Chinese Men. PLoS ONE 7(6): e39234. doi:10.1371/journal.pone.0039234
- O’Connor DB, Lee DM, Corona G, Forti G, Tajar A, et al. (2011) The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men. J Clin Endocrinol Metab 96: E1577–E1587.
- David J, Edwards D, Wright P (2017) REVITALISE audit: Erectile dysfunction and testosterone review in primary care. Diabetes & Primary Care 19: 67–72.
- Jain P, Rademaker AW, McVary KT. Testosterone supplementation for erectile dysfunction: results of a meta-analysis. J Urol 2000; 164: 371–375.
- The American Journal of Medicine (2007) 120, 151-157.
Corresponding Author
Dr Allasatyanarayana Reddy
Leo Institute of Sexual Medicine, Rajbhavan Road, Somajiguda, Hydertabad, India 500082