Abstract
Sildenafil causes vasodilatation by relaxing smooth muscles of blood vessels, enhances endometrial development. Improving endometrial thickness is one of the cornerstones in the management of infertility
Aim of the study: To evaluate the role of Sildenafil on endometrial characters in ovulation induction cycle.
Materials and Methods: 50 infertile women with thin endometrium were randomly divided into two groups. Group A comprised of 25 women in whom clomiphene citrate 50 mg daily from D2 to D6 along with estradiol valerate 2 mg thrice daily from D2 and Group B of 25 women in whom clomiphene citrate 50 mg daily from D2 to D6, estradiol valerate 2 mg thrice daily from D2 and sildenafil citrate 25 mg vaginally thrice daily from D7 to the day of ovulation trigger were given. Trans-vaginal ultrasound was done on alternate days from D8 of cycle for monitoring of follicular development and endometrial characters.HCG trigger was given once the dominant follicle reached >18 mm. Total three cycles of ovulation were studied.
Results: Monitoring of endometrial characters in all the ovulation induced cycles showed significant improvement in Group B. In Group B Mean endometrial thickness was 10.2±1.6mm whereas it is 8.53±1.4 mm in Group A; trilaminar pattern was 93.54% in group B compared to 40.29% in Group A; Zone 4 endometrium was 79.03% in Group B compared to 26.86% in Group A; clinical pregnancy rate per cycle was 20.96% in Group B compared to 13.45% in Group A.
Conclusion: Addition of vaginal Sildenafil to estradiol valerate has significant effect in improving endometrial characters and clinical pregnancy rates in ovulation induction cycles.
Keywords: Sildenafil; Estradiol; Endometrium.
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Corresponding Author
Dr Alla Satyanarayana Reddy
Professor in OBG, Vinayaka Mission`s Medical College & Hospital, Karaikal, Pondicherry, India. 609609
DOI: https://dx.doi.org/10.18535/jmscr/v8i5.62
