Abstract

Background: Clinical significance of Sub-Clinical Hypothyroidism (SCH) is because of its high prevalence, risk of progression to overt hypothyroidism (OH), serious complications like neurobehavioral and cardiovascular disorders and poor quality of life because of non-specific symptoms. Cardiovascular complications occur in these patients is because of un-favorable lipid profile.

Methods: This prospective observational study was carried out in the Department of Medicine MGM Medical College and MY Hospital Indore from January 2017 to June 2018 enrolling total 100 patients.

Results: In normal subject, the mean total cholesterol was 125.92±43.38mg/dl, in SCH patients it was 117.14±39.33mg/dl, showing a higher mean total cholesterol in SCH patients as compared to normal subjects, and the difference came out to be statistically significant (P<0.05). In normal subject, the mean triglyceride was 80.72±13.03mg/dl, in SCH patients it was 123±74.34mg/dl, showing a higher mean triglycerides in SCH patients as compared to normal subjects and the difference was found to be statistically significant (P<0.05). In normal subject, the VLDL was 16.12±2.72 mg/dl, in SCH patients it was 26.05±16.80mg/dl, showing a higher mean VLDL in SCH patients as compared to normal subjects. The difference was statistically significant (P<0.05).

Conclusions: SCH is associated with slight increase in TC, TG, VLDL, and LDL levels and decrease in HDL. Increased TC, TG, VLDL, and LDL in high normal range and decreased HDL in low normal range indicating trend towards atherogenic lipid profile. Thus SCH is associated with increased cardiovascular risk due lipid profile derangements.

Keywords: Cholesterol, subclinical hypothyroidism, overt hypothyroidism, triglyceride.