Background: India accounts for higher incidence of oral and oropharyngeal cancer. For early stage chemoradiation or surgery are equally effective. For advanced stage chemoradiotherapy is the treatment of choice. Conventional radiotherapy requires 2Gy per fraction, with 5 fraction per week. Accelarated repopulation sets in 4^th weeks of conventional radiotherapy. To overcome this effect hypofractionated radiotherapy may be useful. This study was designed to compare conventional radiotherapy with hypofractionated radiotherapy

Materials and Methods: Total 56 patients (28 patients in each arm)were selected from the cross section of patients registered at tertiary care hospital with histologically proven squamous cell carcinoma of oral cavity from Oct 2017 to July 2019.Data obtained from study was compared to find out differences in term of response, acute and chronic treatment realated toxicity

Results: 39.14% patients(9) in arm A and 36%(9) in arm B had complete response,56;52%(13) in arm A and 48%(12)had partial response in arm B ,4.34%(1) in arm A and 16%(4) in arm B were lost to follow up

Conclusions: Hypofractionated radiotherapy has a comparable response to conventional radiotherapy with slight more acute and late but manageable treatment related toxicity with significantly reduced (3wks) treatment time.

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Sanjay Kumar Verma

Resident, JK Cancer G.S.V.M. Medical College Kanpur Uttar Pradesh