Abstract

Acute Myocardial Infarction is one of the most common diagnosis in hospitalised patients. The most common cause of myocardial ischemia is atherosclerotic disease .In patients with acute myocardial infarction, elevated concentration of inflammatory markers are correlated with worse clinical outcome. Now- a- days attention has been focused on various novel inflammatory markers, especially C -reactive protein (CRP) .Our aim was the correlation of C reactive protein in acute myocardial infarction, and determine its significance in prognosis.

Methods: Patients who have been diagnosed as acute myocardial infarction (ST Elevation Acute myocardial Infarction or Unstable angina/Non ST Elevation Myocardial Infarction) and admitted to Patna Medical College and Hospital were the subjects. Sample consisted of 60 cases of acute myocardial infarction. Patients more than 60 years were taken as subjects. Apart from routine blood investigations, serum cardiac biomarkers, electrocardiography and echocardiography was done in all patients. All patients were followed up and observed for the development of complications. 

Results: Maximum incidence of acute coronary syndrome was observed in age group between 61 to 70 years. Out of 60 patients with acute myocardial infarction, 41 patients had STEMI and 19 patients had UA/NSTEMI. According to qualitative method of assay of C- reactive protein estimation, a level, equal to or more than 0.6 mg/dL is detected as positive. A level below 0.6 mg/dL is denoted as negative. In our study, among 60 patients 46(76%) patients had C reactive protein levels positive(highly significant, p<0.001)  and 14(24%.) had CRP value negative.

Conclusion: These findings suggest high CRP has positive correlation in patients with acute myocardial infarction. Raised Plasma CRP levels in majority of patients with AMI suggests involvement of inflammation in MI