Title: Detection of Metallo-β-lactamase producing gene (bla VIM) among gram negative non-fermenting bacteria causing wound infection in patients attending a tertiary care hospital in Kolkata
Authors: Priyanka Chakrabarty, Ushnish Chakrabarty
DOI: https://dx.doi.org/10.18535/jmscr/v8i2.59
Abstract
The introduction of Carbapenems into clinical practice represented a great advance for the treatment of serious bacterial infection caused by β- lactam resistant bacteria. Carbapenem resistance has been observed more commonly in non-fermenters such as Pseudomonas and Acinetobacter species. The common form of resistance is through lack of drug penetration i.e. porin mutations and efflux pumps and for carbapenem –hydrolysing β-lactamases. Acquired MBL have recently emerged as one of the most worrisome resistance mechanisms owing to their capacity to hydrolyse all β-lactams including carbapenems. Hence, in this study we tried to find out the prevalence of metallo- β- lactamase producing gene (blaVIM ) among non fermenting gram negative bacilli causing wound infections from the pus samples received in the Department of Microbiology; Medical College, Kolkata over a period of one year. We found the prevalence to be 7.36%.
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