Title: Obstetric and Neonatal Outcome of Induction of Labour at term with Sublingual Misoprostol as Compared to Intravaginal Misoprostol
Authors: Dr Raga Malika Devi Gontla, Dr Shailaja Prasad, Dr Anitha, Dr Swetha
DOI: https://dx.doi.org/10.18535/jmscr/v8i2.26
Abstract
Background: Misoprostol, a synthetic prostaglandin E1 analog, has been given both orally and vaginally for induction of labor at term. Due to the difference in pharmacokinetics of sublingual as compared to vaginally administered misoprostol, hence this study.
Aim: To study Obstetric and Neonatal outcome of induction of labour with sublingual misoprostolas compared to intravaginal misoprostol.
Method: 120 women with singleton pregnancy with no Cephalo-pelvic disproportion were randomized to receive Tab. Misoprostol 25mcg at 4 hour interval by vaginal route (60 patients) and sublingual route (60 patients).
Results: With sublingual route of administration the number of doses of misoprostol used was significantly lower [p<0.05], reduced induction delivery interval [p<0.05], reduced pelvic examinations [p<0.05] when compared to vaginal route of administration. No difference in maternal and foetal complications.
