Title: Study of serum uric acid in Type 2 diabetes mellitus
Authors: Dr Uddhav Khaire, Dr Rahul Rathod, Dr Pramod Wattamwar
DOI: https://dx.doi.org/10.18535/jmscr/v8i2.11
Abstract
Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycemia associated with impairment in the metabolism of carbohydrates, lipids and proteins. Uric acid is the end product of purine catabolism. Excessive serum uric acid accumulation can cause various diseases. For more than 50 years, increased serum levels of uric acid have been implicated in cardiovascular disease. Different mechanisms have been suggested through which uric acid may be involved in the atherosclerotic process and its clinical complications. Uric acid may act as a pro-oxidant, particularly at increased concentrations, and may be a marker of oxidative stress. The Morbidity and mortality due to non-communicable diseases specially attributed to diabetes mellitus and coronary heart disease is rising rapidly in India, causing nearly 5.8 million deaths per year annually. Considering the strong association between the levels of serum uric acid and the occurrence of coronary atherosclerosis in subjects with type 2 diabetes mellitus, the current study has been undertaken to assess the factors influencing the serum uric acid levels in patients with type 2 diabetes mellitus.
Objectives: To find out association between serum uric acid level and type 2 Diabetes Mellitus. Also correlate serum uric acid level to duration of type 2 Diabetes Mellitus.
Materials and Methods: This was a Case control study comparing between two groups of age and sex matched population.
Results: The mean serum uric acid level of diabetes mellitus of cases 5.10 and that of controls is 3.73 and the p value is 0.04 which is statistically significant. It shows that as duration of DM increases there is significant rise in Serum Uric acid level
Conclusion: Also there is a significant positive correlation between the levels of serum uric acid duration of DM and comorbidities in type 2 DM.
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