Title: A Study of Current Trend of Sepsis Causative Organisms (Fungal and Bacterial) in Neonatal Blood Culture and their Drug Susceptibility Patterns at a Tertiary Care Hospital, Visakhapatnam, South India
Authors: Dr Rakesh Penta, Dr Rajasri Jalla, Dr Surya Bharathi Aripaka
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.165
Abstract
Background
Sepsis is one of the major causes of morbidity and mortality in new borns. it is the clinical manifestation of systemic infection during the first 28 days of life. It is classified as early onset (<72hrs) and late onset (>72hrs) of sepsis. By knowing the current spectrum of pathogens causing sepsis and their drug sensitivity pattern most cases of neonatal sepsis can be saved by prescribing appropriate drugs before culture report collected. Antibiotics may be lifesaving for the few infants who are truly infected. However, broad spectrum antibiotics increase colonization with drug resistant organisms and injudicious use of antibiotics increases antimicrobial resistance. In a critically ill neonate with negative blood culture Fungal sepsis should be suspected. Although Candida albicans has historically been most frequently isolated with good response to flucanazole but now a day’s non albicans candida have emerged as one of the common pathogen. This change in trend may be due to resistance of candida species to azoles .According to pooled hospital data based on NNPD(national neonatal perinatal data) survey, the incidence of neonatal sepsis is around 30/1000 livebirths and this incidenceis1 to8 cases in 1000livebirths in United States1.
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