Maternal factors greatly influence the neonatal congenital anomalies Infection of the fetus by rubella, cytomegalovirus, varicella and toxoplasma can be teratogenic¹³. Exposure of the fetus to some medication can cause congenital anomalies. Some maternal health conditions have shown increased risks for congenital anomalies including obesity, insulin-dependent diabetes, various forms of folate deficiencies and phenylketonuria¹⁹. Pregnancy induced hypertension, vaginal bleeding early in pregnancy, twin pregnancy, oligohydramnios, polyhydramnios, breech presentation, period of gestation, antenatal care during pregnancy, history of previous abortions and still  births have been observed to be maternal factors associated with congenital anomalies.

Aims and Objective: To study the proportion of congenital anomalies at tertiary rural health careand to find the corelation in between the antenatal maternal illness maternal teratogenicity, cooking sources of the mother  consangineous marriage , liquor status of anc on usg and neonatal congenital anomalies

Sample Size: We took a sample size of 150 patients.. All neonates diagnosed with any congenital anomalies born in or coming to nicu of prh.

Results: Proportion of congenital anomalies were seen more in consanguineous marriage and in the mothers with antenatal illness .teratogenicity also had a significant rolec.

Conclusion: Regular check up of the mother and proper counseling for non addiction and avoidance of consanguineous marriage and simple diagnostic means such as x-ray and ultrasound can help in reducing the number of anomalies.

1. Shawky RM, Sadik DI: Congenital malformations prevalent among Egyptian children and associated risk factors. Egyptian Journal of Medical Human Genetics 2011, 12:69–78.
2. Congenital Anomalies in Canada. Perinatal Health report 2002.
3. library.downstate.edu/Teratology Schatz C.I, Barlow M. V. 4:119-130, 1971
4. Joao EC, Calvet GA, Krauss MR, Hance F, Ortiz J, Ivalo SA: Maternal antiretroviral use during pregnancy and infant congenital anomalies. J acquir immun defic syndr 2011, 53:176–85.
5. Little J, Cardy a, Arslan MT, Gilmour M, Mossey P: Smoking and orofacial clefts: a United Kingdom-based case-control study. Cleft Palate Craniofac J. 2004, 41:381–6.
6. Executive Summary March of Dimes Birth Defects Foundation ,Report on birth defects 2006
7. Parmar A, Akruti et al. A study of Congenital anomalies in Newborn. National journal of Integrated Research in Medicine 2017,11;1: 13 – 17
8. Moore KL, Persaud TVN. Human Birth defects. In: The Developing Human, Clinically Oriented Embryology. Philladelphia Saunders 2003, p16–22.
9. Green RF, Sc MM, Ph D, Devine O, Crider KS, Olney S: Association of paternal age and risk for major congenital malformations from the National birth defect prevention study. Ann Epidemiol 2011, 20:241–9.
10. Egbe A, Uppu S, Lee S, Stroustrup A, Ho D, Srivastava S. Congenital malformations in the Newborn Population: A population study and analysis of the effect of Sex and Prematurity. Paediatrics and Neonatology 2015,56:25 – 30
11. Katarzyna Wisniewska, Jacek Wysocki: The importance of folic acid in the primary prevention of congenital malformations. Archives of Perinatal Medicine 2008, 14:32–40.
12. Godwin KA, Sibbald B, Bedard T, Kuzeljevic B, Lowry RB, Arbour L: Changes in Frequencies of Select Congenital Anomalies since the Onset of Folic Acid Fortification in a Canadian birth registry. Canadian Journal of Public Health 2008, 99:271–5.
13. Ramagopalan S V, Guimond C, Criscuoli M, Dyment D: Congenital abnormalities and multiple sclerosis. BMC neurology 2010, 10:115.
14. Perucca E. Birth defects after prenatal exposure to antiepileptic drugs. Lancet Neuro.2005;4(11) : 781- 6.
15. Congenital Anomalies in Canada. Perinatal Health report 2002.
16. Queißer-luft A, Spranger J: Congenital Malformations. Dtsch Arztebl 2006, 103:A2464-71
17. Okru I, Na E, Djece Z. Environmental impact on children's health. Medicina 2007, 43:9–100.
18. European Surveillance of Congenital Anomalies (EUROCAT) Final Activity Report 2002-2003. 46
19. StollC, Alembik Y, Roth MP, Dott B. Study of 224 Cases of Oligohydramnios and Congenital Malformations in a series of 225,669 consecutive births. Community Genet 1998;1:71- 77
20. Taksande A, Vilhekar K, Chaturvedi P, Jain M: Congenital malformations at birth in Central India: A rural medical college hospital based data. Indian journal of human genetics 2010, 16:159–63.
21. Manea A, Timisoara P: Methods to diagnose congenital malformations in newborns. Jurnalul pediatrului 2009,12:10–5.
22. Christianson A, Howson CP, Modell B: March of Dimes. Global report on Birth Defects 2006.
23. A Anand J.S., Javdekar .B.B., Belani .M; Congenital malformations in 2000 consecutive births; Indian Pediatrics: 1998, 25: 845-851
24. Verma M, Chatwal, Singh D; Congenital malformation a retrospective study of 10,000 cases: Ind Jr Pediatr 1991; 58:245-252.
25. Mathur B.C, Karan W.S, Vijayadevi K.K; Congenital malformations in newborn; Ind Pediatr; 1975;12:179-181.
26. Saifulla S, Chandre R.K, Pathak L.C; Congenital malformations in newborn; Ind Pediatr; 1967;4:251-261
27. Bhat .B.V., Babu .L., Congenital Malformations at birth-a prospective study from south India; Indian Journal of Pediatrics: 1998 Nov-Dee; 65(6):873-81
28. Agrawal .S.S., Usha Singh, Vineeta Das: Prevalence and spectrum of congenital malformations in a prospective study in a teaching Hospital; Indian Journal Medical Research: Dec 1991; 94: 413-419.

Dr Sayed Asif Umar