Abstract
Background: The assessment of severity in acute pancreatitis is very important as 20% of cases can progress to serious life-threatening events. Several multifactorial scoring systems are widely used; but they are too cumbersome to use in daily clinical practice. A single test which has a predictive power of prognostication is serum C-reactive protein.
Aims: To assess the relative accuracy of serum C-reactive protein and Ranson’s scoring system in predicting the severity of acute pancreatitis. To evaluate the accuracy of serum C-reactive protein in monitoring the clinical course of the disease
Materials and Methods: it is a prospective study done on all patients admitted in the institution over a period of one year, who were diagnosed with acute pancreatitis.
Results: A total of 42 patients were studied. Thirty patients had mild acute pancreatitis and 12 had severe. Ranson’s criteria predicted 16 patients to have severe pancreatitis, whereas only 8 cases turned out to be severe. CRP estimation predicted 14 to be severe, of which, 10 patients had a severe outcome. Ranson’s criteria showed a sensitivity of 66.6%; specificity of 73.3% and accuracy of 71.4; whereas, serum CRP showed a sensitivity of 83.3; specificity of 86.6% and accuracy of 85.7%.
Conclusion: Serum CRP shows a higher prognostic sensitivity and accuracy than Ranson’s scoring system. CRP as a single parameter can be used to predict the development of complications in acute pancreatitis. It is a good early marker for the severity of acute pancreatitis. The CRP value at the end of the first week is useful in monitoring the clinical course.
Keywords: Acute pancreatitis, Ranson’s criteria, Serum C-reactive protein,Severe acute pancreatitis
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Corresponding Author
Reeja R.
Associate Professor, Department of Pharmacology, Govt. Medical College, Kollam, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.80
