Abstract
Antibiotics are second leading offending agent implicated in perioperative anaphylaxis. Here, we report a case of intraoperative anaphylaxis to Cefotaxime which presented as sudden cardiovascular collapse without apparent cutaneous signs. However, massive pulmonary edema became the prominent feature of this anaphylactic reaction. This again emphasises need for vigilance and promptness of anaesthesiologist towards occurrence of perioperative anaphylaxis and varied presentations.
Keywords: Anaphylaxis, Pulmonary edema, Cefotaxime, Adrenaline.
References
- Gandhi R, Sharma B, Sood J et al. Anaphylaxis during anesthesia : Indian scenario . IJA. 2017;61: 387-92
- Amit G Bhagat, Kirti N Sarema. Intraoperative Anaphylaxis to Inj. Ceftriaxone: Here We GO Again…. IJA 2008; 52 (4): 462-466.
- Kelkar PS, Li J. Cephalosporin allergy. N Engl J Med. 2001; 345: 804-9.
- Patterson RA, Stankewics HA. Penicillin allergy [Updated 2019Apr23]. State Pearls [Internet]. Treasure Island(FL): State Pearls Publishing; 2019Jan-
- Thirunavukkarasu AB, Vijayan S. Cefotaxime- induced near fatal anaphylaxis in a neonate: A case report and review of literature. Ind J Pharmacol.2011; 43(5):611-12.
- Kumari A, Gupta R, Bajwa SJ. et al. A rare case of ceftriaxone induced anaphylaxis in anesthesia practice . Arch Med Health Sci.2015; 3:106-9
- Tomar GS, Tiwari AK,Chawla S .Anaphylaxis related to fentanyl citrate .J Emerg Trauma Shock. 2012; 5(3): 257-61.
- Reber LL, Hernandez, Galli SJ .The pathophysiolory of anaphylaxis. J Allergy Clin Immunol .2017; 140(2); 335-48.
- Mali S, Jambure R. Anaphyllaxis management: Current concepts .Anesth, Essays Res 2012; 6(2) : 115 -23.
- Aboul- Fotouh S , Maggdy YM ,Ali RM. A case report of systole after a test dose of ceftriaxone in an adult man . Ain-Shams J Anaesthesiol.2016 ; 9:617-19
- Brockow K. Romano A. Blanca M. et al. General considerations for skin test peocedures in the diagnosis of drug hypersensitivity .Allergy. 2002; 57(1): 45- 51.
Corresponding Author
Dr Vrishali Ankalwar
Associate Professor, Dept. of Anaesthesiology, GMCH, Nagpur, Maharashtra 440013