Background and Aims: To determine the effect of concomitantly administered ondansetron on duration of post operative analgesia of tramadol hydrochloride in patients undergoing  gynarcological surgeries

To compare the incidence of post operative vomiting between Tramadol group and Tramadol-ondansetron group.

Methods: The study was approved by our Institution of Ethics Committee and all patients provided written informed consent.  Sixty patients in the age group of 25 to 65 years belonging to ASA physical status I and II were induded in a prospective double blind randomized study. All patients were scheduled for elective Gynaecological surgeries under subarachnoid block:

Results: The duration of analgesia in both groups were assessed with VAS pain score. Tramadol group had better mean duration of analgesia, 327 minutes than the concomitant group, 220 minutes p value < 0.001.

Conclusion: Is the post operative use of Tramadol cannot be recommended with ondansetron as the first choice of the antiemetic, because ondansetron reduces the analgesic power of Tramadol on post operative pain.

Keywords: Tramadol, ondansetron spinal anaesthesia.

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Dr Prabhash .R

Associate Professor, Govt. Medical College, Manjeri