Abstract
Gallbladder carcinoma is the 5th most common gastrointestinal tract cancers and is an aggressive malignancy with varied presentation. The predominant sites of mestatasis being liver and regional lymph nodes. Skeletal metastasis in gallbladder carcinoma is very rare and only 15 cases have been reported in English literature so far. In this manuscript, we describe our experience of two cases of skeletal metastasis in carcinoma gallbladder.
Keywords: Gallbladder Cancer, Skeletal Metastasis in Gallbladder Cancer, Bony Metastasis.
References
- Sameer G., Naseem A., Vijay K. et al. Skeletal Metastasis in Gallbladder Cancer from a High-Volume Tertiary Care Center of North Inida: a Series of Rare Occurrence. J Gastrointest Canc (2015) 46: 36-41
- Shivendra Singh., et al. “Skeletal metastasis in gall bladder cancer”. HPB (Oxford) 9.1 (2007): 71-72.
- Arminski TC. Primary carcinoma of the gallbladder: a collective review with the addition of 25 cases from the Grace Hospital, Detroit, Michigan. Cancer 1949;2:379–98. doi:10.1002/1097-0142(194905)2:3<379::AID-CNCR2820020303>3.0.CO;2-Q.
- Kumar A, Bhargava S K, Upreti L. Kumar J. Disseminated osteoblastic skeletal metastases from carcinoma of gallbladder – a case report, Indian J Radiol Imaging 2003;13:37-7
- Kohli A, Chib RS, Parihar BK. Secondary involvement of femur in carcinoma of gall bladder. Indian J Cancer. 1994 Dec;31(4): 257-9.
- Misra S, Chaturvedi A, Misra NC. Carcinoma gall bladder presenting with skeletal metastasis. Indian J Gastroenterol 1997;16:74.
- Pandey M, Aryya NC, Pradhan S, Asthana AK, Gautam A, Shukla VK. Carcinoma of the gallbladder presenting as scalp tumour. Eur J Surg Oncol. 1998;24:605–7.
- F Youssef, AW Khan, Br Davidson. Disseminated bony metastases following incidental gallbladder cancer detected after laparoscopic cholecystectomy. HPB (Oxford). 2003; 5(4): 258-260.
- Jain G, Samaiya A, Mohindra N, Patel K. Bone metastasis as the initial presentation of carcinoma of gall bladder: A rarity. Indian J Surg. 2009;71:35–7.
- Kulkarni M, Ramachandran V, Dash NR et al. Isolated Scapular Metastasis in a Patient with Gallbladder Carcinoma: Case Report. The Open Surgical Oncology Journal, 2009, 1, 10-11.
- Prakash M, Aiyappan, Kumar A et ai. Solitary skeletal metastasis in carcinoma gallbladder: two case reports. Cancer Imaging. 2010; 10(1): 121-123.
- Win AZ, Aparici CM. Rare case of gallbladder cancer presenting with metastasis to bone and brain in an African American male discovered by F18-FDG PET/CT. J Biomed Graph Comput. 2013;3 (2):24–29.
- Joshi MK, Joshi R, Chadha M et al. Gall Bladder Carcinoma Presenting with Spinal Metastasis: A Rare Phenomenon. Indian J Palliat Care. 2013. May-Aug; 19(2): 113-115.
- Chaudhary S, Hatwal D, Bhat P. A Rare Presentation of gallbladder Carcinoma Metastasis. J Clin Diagn Res. 2014 June; 8(6): FD19-FD20.
- Joel A, Samuel A, Bhatt A et al. Carcinoma of the gallbladder presenting with multiple osseous and inguinal lymph node metastases. Indian J Cancer 2015;52:230-1.
- Yashant A, Priya H. Skeletal Metastasis From Carcinoma of the Gall bladder: Need for Bone Scintigraphy Justified? Pol J Radiol. 2016; 81: 206-208.
- Varshney VK, Soni SC, Yadav T et al. Gall Bladder Carcinoma with Concurrent Metastases to Bone (Sclerotic) and Urinary Bladder. Journal of Clinical and Diagnostic Researsch. 2018 Jan. Vol-12(1): PD06-PD08.
- Yochum tr and rowel j. tumor and tumor like processes. In: yochum tr and rowel j, ed. Essentials of skeletal radiology. 1st edn. Baltimore, Maryland, USA. Williams and Wilkins, 1987; 975-1192.
- Memon MA, Anwar S, Shiwani MH, Memon B (2005) Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital. Int SeminSurg Oncol 17;2(1):63.
Corresponding Author
Dr Satyendra Narayan Sinha
Radiation Oncology Department, Paras HMRI Hospital, Patna (India)
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.02
