Abstract
It is estimated that there are almost 1.3 million new cases of prostate cancer, ranking as the second most frequent cancer and the fifth leading cause of cancer death in men. It is the most frequently diagnosed cancer among men in over one-half (105 of 185) of the countries of the world.
Prostate cancer presenting as cervical lymphadenopathy as initial presentation is rare while most present with genitourinary symptoms. We present a case of a 97 years-old male who presented with supraclavicular lymphadenopathy as the primary complaint. FNAC from lymph node revealed metastatic adenocarcinoma. CECT chest and abdomen revealed large left cervical lymphadenopathy with few subcentimetric pre and paraaortic lymph nodes without any other obvious lesion. Serum PSA was grossly elevated with value 269 ng/ml, based on PSA value diagnosis of metastatic carcinoma of prostate was made.
Keywords: Prostate, cervical lymphadenopathy, PSA.
References
- Bray F, Ferlay J, et al. Globocan Cancer Statistics 2018: Globocan Estimates of Incidence and Mortality Worldwide for 36 cancers in 185 Countries. CA: Cancer J Clin. 2018; 0:1-31.
- Carleton J, P Vander Riet, Dahm P: Metastatic Prostate cancer presenting as an asymptomatic neck mass. Prostate Cancer and Prostatic Diseases, 2005; 8: 293–95
- P. J. Yardley, “Investigation of cervical lymphadenopathy presumed to be metastatic in nature: a review of current clinical practice,” Journal of the Royal College of Surgeons of Edinburgh, vol. 37, no. 5, pp. 319–321, 1992.
- Platania M, Bajetta E, Guodalupi V et al: Prostate adenocarcinoma presenting with supraclavicular node enlargement: report of a case. Tumori, 2008; 94: 769–71
- Cho KR, Epstein JI: Metastatic prostatic carcinoma to supradiaphragmatic lymph nodes, a clinicopathologic and immunohistochemical study. Am J Surg Pathol, 1987; 11: 457–63
- N Eke, MK Sapira: Prostate cancer in Port Harcourt, Nigeria: features and outcome. Nigerian Journal of Surgical Research, 2002; 4(1): 34–44
- Lin YY, Lin DS, Kang BH, Lin YS. Neck mass as the first presentation of metastatic prostatic adenocarcinoma. J Chin Med Assoc 2011;74:570-73.
- Batson OV (1995) The function of the vertebral veins and their role in the spread of metastases. Clin Orthop Relat Res 312: 4-9.
- Jones and P. P. Anthony, “Metastatic prostatic carcinoma presenting as left-sided cervical lymphadenopathy: a series of 11 cases,” Histopathology, vol. 21, no. 2, pp. 149–154, 1992.
- Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J, Satoh T. Metastatic patterns of prostate cancer: correlation between sites and number of organs involved. Cancer 1984;54:3078-84.
- Copeland B et al. Prostate carcinoma metastatic to the cervical lymph nodes: report of two cases and review of the literature. Am J Otolaryngol 2001; 22: 420–423.
- Jones H, Anthony PP. Metastatic prostatic carcinoma presenting as left-sided cervical lymphadenopathy: a series of 11 cases. Histopathology 1992;21:149-54
- Chitale SV, Harry L, Gaches CGC, Ball RY. Presentatio of prostatic adenocarcinoma with cervical lymphadenopathy: two case reports and review of the literature. Otolaryngol Head Neck Surg 2001;125:431-2.
Corresponding Author
Dr Abdul Hakim
Assistant Professor Radiation Oncology, GMC Rajouri, J&K., India