Abstract
Background and Rationale
Over the last decade, cardiovascular disease has become the single largest cause of death worldwide. It is predicted that more cardiovascular risk burden will be borne by the Indian subcontinent in the next decade according to recent epidemiological studies1. There exists significant difference in the prevalence of coronary artery disease with respect to gender, age and ethnicity. Cardiovascular disease [CVD] has emerged as a major health burden in developing countries2. [CVD] is the leading cause of death in India and in the southern Indian state of Kerala5.
In India, prevalence of coronary artery disease (CAD) has been reported as being 11% in 20013. India has the highest burden of acute coronary syndrome [ACS] in the world4.
The health status of Kerala population differs from that of other Indian states owing to its higher literacy rate, better distribution of its healthcare facilities among rural and urban areas, and its better access to healthcare institutions.
References
- Gupta R. Joshi P. MohanV. Reddy K S. Yusufs. Epedemiological and causation of coronary heart disease & stroke in India. Heart 2008;94:16-26.
- Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation 1998; 97;596-601.
- Gupta M, Singh N, Verma S. South Asians and cardiovascular risk: what clinicians should know? circulation 2006;113:e924-9
- Mohan V, Deepa R, Rani SS, Premalatha G. Prevalence of coronary artery disease and its relationship to lipids in a selected population in South India: the Chennai Urban Population Study (Cups No. 5). J Am Coll Cardiol 2001; 38:682-7. Comment in: p. 688-9.
- Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy KS, et al. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet 2008; 371(9622): 1435-42. 13.
- Report on Causes of Death in India,2001-2003. Registrar General of India. New Delhi, India, 2009.
- Wissler R.W. (1995) An overview of the quantitative influence of several risk factors on progression of atherosclerosis in young people in the United States. Am J Med Sci 310(suppl 1):29–36.
- Wissler R.W. (1994) The PDAY Collaborating Investigators. New insights into the pathogenesis of atherosclerosis as revealed by PDAY. Atherosclerosis 108 (suppl):S3–S20
- Ockene JK, Kuller LH, Svendsen KH, Meilahn E. The relationship of smoking cessation to coronary heart disease and lung cancer in the Multiple Risk Factor Intervention Trial (MRFIT). Am J Public Health.1990;80:954–958.
- Cutler JA, Psaty BM, MacMahon S, Furberg CD. Public health issues in hypertension control: what has been learned from clinical trials. In: Laragh JH, Brenner BM, eds. Hypertension: Pathophysiology, Diagnosis and Management. 2nd ed. New York, NY: Raven Press, Ltd; 1995.
- Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). 1994; 344:1383–1389.
- http://www.mayoclinic.org/diseases-conditions/acute-coronary-syndrome/basics/risk-factors/con-20033942
- http://medind.nic.in/iby/t07/i10/ibyt07i10p300.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847940/
- http://eurheartjsupp.oxfordjournals.org/content/16/suppl_A/A80.full.
- http://www.hellenicjcardiol.com/archive/full_text/2010/4/2010_4_294.pdf.
- http://www.ncbi.nlm.nih.gov/pubmed/19645040.
Corresponding Author
Dr Indra. N
Assistant Professor, Department of Physiology, Believers Church Medical College, Thiruvalla, Kerala, India