Abstract
Objective: There was a link among Level of prostate cancer (PCa), symptoms of lower urinary tract and chronic prostatitis (CP) histology, despite there was uncertainty with this clinical meaning. We pursue a retrospective analysis of existing patient’s data at a Patna based hospital to establish the link between diagnosis of PCa and role of CP.
Methods: Hospital database were used to fetch required data for patients who had undergoing prostate biopsy with all histological findings of chronic prostatitis from April 2015 to March 2019. Patients were categorised on basis of Without Chronic Prostatitis and With Chronic Prostatitis. Using univariate and multivariate analyses association between CP and PCa diagnosis was determined.
Result: 657 patients were selected whose average mean age was 68 ± 8.23 years with PSA level of 8.8±1.1 ng/ml. Entire population were categorised on basis of Without Chronic Prostatitis (N=255) and With Chronic Prostatitis (N=402). Between group’s difference of IPSS score, age, prophylactic antibiotic use, PSA, transurethral catheter at biopsy or infectious complications, alpha-blocker or 5-α-reductase inhibitor therapy and comorbidities were statistically insignificant, whereas number of cores taken, cancer diagnosis, prostate volume, suspicious digital prostate exam, previous biopsy and hospitalizations and Gleason score >=7 differences were found the be statistically significant. Protective effect between CP and diagnosis of PCa was shown by a multivariate analysis model (HR 0.14, p= <0.01).
Conclusion: This observation suggest that PCa diagnosis is inversely related to histological finding of CP.
Keywords: Prostate Biopsy; Chronic Prostatitis, Prostate Cancer.
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Corresponding Author
Dr Khalid Mahmood
Indira Gandhi Institute of Medical Sciences Campus, D type6/4, Sheikhpura, Patna, Bihar 800014, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.66
