Abstract
Background and Objectives: Cerebrovascular disease with stroke in particular is one of the most important causes of death and the greatest cause of disability all over the world. Stenosis degree is considered the leading parameter in the choice of therapeutic options but factors other than the degree of stenosis are also important in assessing whether a carotid lesion will remain clinically silent. Ulcerated plaques are associated with a higher risk of embolism and occlusion, producing ischemic neurologic events.
The purpose of this study was to evaluate the diagnostic efficacy of multidetector row CT angiography (MDCTA) and US-ECD in the evaluation of carotid plaque complicated by ulceration with MDCT being taken as reference standard
Methods: Total of 30 patients with symptoms pertaining to cerebrovascular disease were selected over a period of one year and plaque ulceration was evaluated and compared by both Doppler ultrasound and CT angiography.
Results: We concluded that CDUS is inferior w.r.t CTA to assess plaque morphology and especially in identification of ulceration. This can be ascribed, in part, to the fact that acoustic shadowing from calcification obscures ulcers, and the sonography probe may not be parallel to the axis of the vessel in the region of the ulceration. Sonography is limited by its accuracy and reproducibility, especially when the lesion is calcified. The recent development of 3D US and the use of CEUS may help improve the detection of carotid ulceration
Keywords: Plaque ulceration, carotid vascular disease, cerebrovascular disease, Doppler ultrasound, CT angiography.
References
- North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients high with grade stenosis.N Engl J Med 1991;325:445–53
- European Carotid Surgery Trialists’ Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351:1379
- Asymptomatic Carotid Atherosclerosis Group. Endarterectomy for asymptomatic carotid artery stenosis.JAMA 1995; 273:1421–28
- Kim DI, Lee SJ, Lee BB, et al. The relationship between the angiographic findings and the clinical features of carotid artery plaque.Surg Today2000;30:37–42
- Eliasziw M, Streifler JY, Fox AJ, et al. Significance of plaque ulceration in symptomatic patients with high grade carotid stenosis: North American Symptomatic Carotid Endarterectomy Trial.Stroke 1994;25:304–08
- Sitzer M, Muller W, Siebler M, et al. Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke1995;26:1231–33
- Lovett JK, Gallagher PJ, Hands LJ, Walton J, Rothwell PM. Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation 2004; 110:2190-7.
- Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33:159-74.
- Ackerman RH, Candia MR. Assessment of carotid artery stenosis by MR angiography. AJNR Am J Neuroradiol 1992;13:1005–08
- Smith RR, Russell WF, Percy ML Ultra structure of carotid plaques. Surg Neurol 1980;14:145–53 pmid:7414501
- Hertzer NR, Beven EG, Benjamin SP Ultramicroscopic ulcerations and thrombi of the carotid bifurcation. Arch Surg 1977;112:1394-1402 doi:10.1001/archsurg.1977.01370110128015 pmid:921536
- Homburg PJ, Rozie S, van Gils MJ, et al Association between carotid artery plaque ulceration and plaque composition evaluated with multidetector CT angiography. Stroke 2011;42:367–72 doi:10.1161/STROKEAHA.110.597369pmid:21183745
- Berg M, Zhang Z, Ikonen A, et al.Multi-detector row CT angiography in the assessment of carotid artery disease in symptomatic patients: comparison with rotational angiography and digital subtraction angiography. AJNR Am J Neuroradiol 2005;26:1022–34 pmid:15891155
- Saba L, Caddeo G, Sanfilippo R, et al. CT and ultrasound in the study of ulcerated carotid plaque compared with surgical results: potentialities and advantages of multidetector row CT angiography. AJNR Am J Neuroradiol2007;28:1061–66 doi:10.3174/ajnr.A0486 pmid:17569958
- Saba L, Sanfilippo R, Sannia S, et al Association between carotid artery plaque volume, composition, and ulceration: a retrospective assessment with MDCT. AJR Am J Roentgenol 2012;199:151–56 doi:10.2214/AJR.11.6955pmid:2273390
- Wintermark M, Jawadi SS, Rapp JH, et al. High-resolution CT imaging of carotid artery atherosclerotic plaques. AJNR Am J Neuroradiol 2008;29:875–82 doi:10.3174/ajnr.A0950 pmid:18272562
- SamehAbd El Raouf, Amal Amin Abu El Maati, Nivine Chalabi. Agreement between multi-detector-row CT angiography and US-ECD in quantification of carotid artery stenosis and plaque characterization The Egyptian Journal of Radiology and Nuclear Medicine 2014;45:143-150.
- Saba L, Sanfilippo R, Montisci R, Atzeni M, Ribuffo D, Mallarini G. Vulnerable plaque: detection of agreement between multi-detector-row CT angiography and US-ECD. Eur J Radiol. 2011;77(3):509-15.
- Reitera M, Horvatb R, Puchnera S, et al. Plaque Imaging of the Internal Carotid Artery – Correlation of B-Flow Imaging with Histopatology. Am J Neuroradiol. 2007;28:122–6.
- Lukanova DV, Nikolov NK, Genova KZ, Stankev MD, Georgieva EV. The Accuracy of Noninvasive Imaging Techniques in Diagnosis of Carotid Plaque Morphology. Open Access Maced J Med Sci. 2015;3(2):224-30
- Liapis C, Kakisis J, Kostakis A. Carotid stenosis:factors affecting symptomatology. Stroke. 2001;32:2782–86.
- Cai J, Hatsukami T, Ferguson M, et al. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation. 2002;106:1368–73
- Ajduk M, Bulimba S, Pavi L. Comparison of Multidetector-Row Computed Tomography and Duplex Doppler Ultrasonography in Detecting Atherosclerotic Carotid Plaques Compl-icated with Intraplaque Hemorrhage. CollAntropol. 2013;37:213–9.
- Walker LJ, Ismail Á, McMeekin W, et al. Computed tomography angiography for the evaluation of carotid atherosclerotic plaque: correlation with histopathology of endarterectomy specimens.Stroke 2002; 33:977–81.
Corresponding Author
Dr Ambuj Shandil
Civil Hospital Theog, Shimla, H.P (India)