Title: Cytomorphological Evaluations of Malignant effusion in tertiary care center in central India- A hospital based study
Authors: Dr Jai Bharat Singh, Dr Anand Bhadkariya, Dr Vijay Chaudhary, Dr Dimple A Bhadkariya, Dr Arjun Singh
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.42
Abstract
Introduction: Fluid can build up in the abdomen or chest, putting pressure on the internal organs. Examinations of the effusion fluid are very easy and relatively non-invasive technique for diagnosis. It has provided much information to helpful to patients diagnostically as well as therapeutically. The morphological examinations of the cells are helpful to diagnose as primary and secondary sites of malignancy that means its help prognostic evaluations of the diseases.
Material and Method: This prospective study was conducted in the Department of Pathology in Ruxmaniben Deepchand Gardi Medical College, Ujjain. Eighty-eight cases were included in this study.
Result: We studied 88 effusion fluids in which 37 (42.04%) effusions were inflammatory with predominance of inflammatory cells to reactive mesothelial cells, followed by 20 (39.5%) fluids showing malignant metastatic deposits. Grossly out of 88 effusions, 57 (64.0%) fluids were straw colored while rest 31/88 (35.9%) were reddish. Twenty-five malignant effusions were reddish appearance, while only six malignant effusions (19.3%) were of straw-colored. Inflammatory fluids showed lymphocyte as the predominant cells.
Discussion: In present study cytological evaluation and routine staining of 88 cases with serous effusion was performed. On microscopy, apart from frankly malignant and other cases classified as inflammatory, or reactive effusion few cases were having variable number of cells with relatively large and rather hyperchromatic nuclei These cells were isolated or occurred in small clusters and could best be defined as suspicious. On white cell count, 68.1% effusion had white cell counts less than 1000 cells/mm3 and most of these effusions were either inflammatory or suspicious for malignancy. We found white cell count > 1000/mm3 in 51.61% (16 /31) of all malignant, effusion and 31.8% (10/31) of malignant effusion were with cell count less than 1000 cells/ mm3.
Keywords: Effusion, Malignancy, Cytology, Cell morphology.
