Abstract
We present a 4 year obese child, with no mass lesion in brain/CNS, normal chest, abdomen & normal peripheral smear, Bone marrow aspirate. There was Subdural Collection and enhancement. CSF cytology showed lymphoma/leukemic infiltration, Immunophenotyping was Precursor B cell lymphoma involving meninges. FISH study showed abnormal signal pattern for BCR-ABL gene indicating trisomy 9.
Keywords: CSF cytology; obese child; Immunophenotyping, B cell lymphoma.
References
- Troy Quigg et al. Hypothalamic Obesity Syndrome: Rare Presentation of CNS+ BCell Lymphoblastic Lymphoma Pediatr Blood Cancer. 2012 November; 59(5): 930–933
- Oussama Abla etal Leptomeningeal Precursor B-Cell Lymphoblastic Lymphoma in a Child With Minimal Bone Marrow Involvement J Pediatr Hematol Onco2l 004;26:469–472
- Felice, et al BRIEF REPORT Diagnosis and Successful Treatment of Childhood Primary Leptomeningeal Lymphoma Medical and Pediatric Oncology 2000 34:361–363
- Oussama Abla, et al Primary CNS Lymphoma in Children and Adolescents: A Descriptive Analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG) Clin Cancer Res. 2011 January 15; 17(2): 346–352
- Jennie W. Taylor Primary leptomeningeal lymphoma International Primary CNS Lymphoma Collaborative Group report Neurology 2013; 81:1690–1696
- OUSSAMA ABLA et al Primary central nervous system lymphoma in children Neurosurg Focus 21 (5):E8, 2006.
Corresponding Author
Dr Ashwini Nargund
Associate Professor, Department of Pathology, Dr M H Marigowda road, Kidwai Cancer Institute, Bengaluru, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.08
