Abstract
Chronic liver disease is an end stage disease and hematological abnormalities are common finding in it, adding morbidity to primary pathology and increase the mortality. The study was conducted to assess the hematological abnormalities and haemostatic derangements in CLD patients in north bihar to reduce the morbidity. Broadly, the hematological abnormities are viewed under abnormalities in RBCS, WBCS, platelets and coagulation profile.
Methods: Total 50 patients who fulfilled our criteria were enrolled in our hospital, DMCH, Darbhanga. Patients were investigated after their oral and written consents wherever required.
Results: Various hematological abnormalities encountered were normocytic, Normo-chromic Anemia, Macrocytic mostly in alcholics, leukocytosis was more compared to leucopenia and thrombocytopenia, increased prothrombin time and APTT.
Conclusion: Every chronic liver disease patients must be evaluated for hematological abnormalities and should be treated accordingly as early possible.
Keywords: Chronic liver disease, hematological abnormalities, anaemia.
References
- McHutchison JG, Manns MP, Longo DL. Definition and Management of anemia in patients infected with hepatitis C virus. Liver Int. 2006; 26: 389-398. (PubMed)
- Middle-East Journal of Scientific Research 7(6): 1001-1007, 2011 ISSN 1990-9233© idosi publications, 2011.
- Lindenbarum J, Lieber CS, Effects of chronic ethanol administration on intestinal absorption in man in the absence of nutritional deficiency. Ann. NY ACad.Sci, 1975, 252: 228-234.
- Fergunson, J. Skikne, B.S, Simpson, K.M., Baynes, R.D & Cook J.D (1992).Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J.Lab. Clini. Med. 1992; 19: 385.
- Haussinger D. In:Oxford text book of hepatology II edition, Bircher J, Benhamou J, McIntyre N, Rizzetto M, Rodes J, Eds, Oxford University Press, Oxford, 1999, pg 325.
- Kimber C, Deller DJ, Ibbotson RH, and Lander H. The mechanism of anaemia in chronic liver disease. Quarterly Journal of Medicine, 1965; 34: 33-64.
- Sheehy TW and Berman A. The anaemia of cirrhosis. Journal of Laboratory and Clinical Medicine, 1960; 56: 72-82.
- Schmidt K, Waever Rasmussen JDahl Rasmussen A, Arendrup H, Comparative studies of the in vivo kinetics of simultaneously injected 111in- and 51Cr-labelled human platelets. Sca J. Hematol, 1983. 30: 465-78.
- Siciliano M, Tomasello D, Milani A, Ricerca BM, Storti S, Rossi L, Reduced serum levels of immuno reactive erythropoietin in patients with cirrhosis and chronic anemia, Hepatology, 1995, 22: 1132-5.
- Piris M, Fabris C, Soardo G, CEcchin E, Toniutto P, Bartoli E, Thrombocytopenia of chronic liver disease corrected by erythropoietin treatment. J. Hepatol, 1994, 21: 376-80.
- Berman I, Axelord AR, and Horan TN. The blood and bone marrow in patients with cirrhosis of the liver. Blood, 1949; 4: 511-33.
Corresponding Author
Dr Jitendra Kumar Singh
PG Resident Medicine Department (Session 2017-2020), Darbhanga Medical College, Darbhanga