Abstract

Objective: Persistent Urinary tract infections (UTI) in Pregnant Women cause poor maternal and perinatal results. Present study was conducted to evaluate the Incidence and Prevalence of Urinary Tract Infections among Pregnant Women and Their Antimicrobial Sensitivity Pattern in Tertiary Care Hospital.

Materials and Methods: A total of 320 Pregnant Women presented with symptoms of UTI were included in the study. From all the Pregnant Women a total of 320 early morning mid stream voided urine samples were collected in sterile urine pot in fully aseptic methods.  All the samples were collected and received to the laboratory without delay for further processing. Routine examination of urine and Culture and sensitivity of samples were done and organism was identified by standard protocol. The organism was isolated and tested for antimicrobial sensitivity pattern by Kirby-Bauer disc diffusion method, according to CLSI guidelines. Antibiotics disk used are Amoxicillin, Amoxicillin+clavulanic acid, Cephalosporins, Naladixic acid, Nitrofurantoin, Cotrimoxazole, and Ciprofloxacin, Norfloxacin.

Results: Out of 320 pregnant women included for the study, 96 pregnant women (30%) have symptomatic bacteriuria and 224 pregnant women (70%) have asymptomatic bacteriuria. The prevalence of bacteriuria among symptomatic and asymptomatic pregnant women were (12.4%), and (15.2%) respectively, with no significant difference between the two groups, and the overall prevalence of UTI was (15%). Age, gestational age, parity, and history of UTI in pregnancy were not associated with bacteriuria. Out of 96 symptomatic pregnant women, 54 isolates were isolated, after culture of urine.  Escherichia coli were 32 (59.26%) and S. aureus 16 (29.63%) were the commonest isolated bacteria, followed by K.Pneumoniae 3 (5.56%), Group B Streptococcus 2 (3.70%) and Pseudomonas aeruginosa was 1 (1.85%).  E. coli isolates, showed resistance to Amoxycillin 5, Naladixic acid 4, Nitrofurantoin 3, Ciprofloxacin5, Co-trimoxazole6, Amoxycillin+Clavulanate 3 and Norfloxacin in 2 isolates.

Conclusion: Escherichia coli were the most prevalent causative organisms and showing multi drug resistance pattern, asymptomatic bacteriuria is more prevalent than symptomatic among pregnant women. During antenatal checkup all the pregnant women is recommended for Urine culture to rule out the symptomatic or asymptomatic bacteriuria so that the complication of pregnancy can be prevented.

Keywords: Urinary Tract Infection, pregnancy, bacteriuria, antibiotic.