Abstract
Aim: The aim of this study is to highlight the histopathological spectrum of ovarian both benign and malignant and to compare our study with findings of other centers.
Materials and Methods: Hematoxylin and eosin stained slides of ovarian biopsies diagnosed at Rajendra Institute of Medical Sciences, Ranchi, Jharkhand for 3 years (January 2016 to December 2018 ) were archived, scrutinized, and studied. Clinical biodata and diagnosis were obtained from the Histopathology section.
Results: A total of 1091 ovarian biopsies were reviewed. Of this, 556 (50.96%) were nonneoplastic. Again 339 (31.08%) were benign neoplastic tumours and 196 (17.96%) were malignant tumours. Out of the 556 nonneoplastic (functional cysts) lesions, follicular cyst was the most commonly encountered, constituting 160 cases (28.78%). The peaks age incidence for nonneoplastic and benign neoplastic lesions occurred in the 3rd decade. Two peaks age incidence was noted for malignant tumors-5th and 7th decades. Germ cell tumor constituted the most common neoplastic ovarian tumour (n = 113; 57.65%) diagnosed.
Conclusion: Functional ovarian cysts were the most commonly encountered ovarian lesions in our study population. The most common variety of functional cyst were follicular cyst and corpus luteum cyst with majority occurring in the reproductive age groups. Among the ovarian tumors, germ cell tumors followed by surface epithelial tumours were most commonly seen.
Keywords: Follicular cyst, luteal cysts, germ cell tumour, surface epithelial tumour.
References
- Kayastha S. Study of ovarian tumours in Nepal medical college Teaching Hospital. Nepal Med Coll J 2009;11:200-2.
- Warner BW, Kuhn JC, Bar LL. Conservative management of large ovarian cysts in children: The value of serial pelvic ultrasonography. Surgery 1992;112:749-55.
- Choudry A, Bangash N, Malik A, Choudry H. Adolescent ovarian tumours: A Clinico-pathological review of 15 cases. J Ayub Med Coll Abottabad 2008;20:18-21.
- Pudasaini S, Lakhey M, Hirachad S, Akhter J, Thapa B. A study of ovarian in a tertiary hospital of Kathmandu Valley. Nepal Med Coll J 2011;13:39-41.
- Merino MJ, Jaffe G. Age contrast in ovarian malignancy pathology. Cancer 1993;15:537-44.
- Malik IA. A prospective study of clinic-pathological features of epithelial ovarian cancer in Pakistan. J Pak Med Assoc 2002;52:155-8.
- Wasim T, Majrroh A, Saddiq S. Comparison of clinical presentation of benign and malignant ovarian tumours. J Pak Med Assoc 2009;59:18-21.
- Maliheh A, Mohammed H, Nadereh M, Mehdi Y, Fazareh G, Mojgan E. Surgical histopathology of benign ovarian cysts: A multicentre study. Iran J Pathol 2010;5:132-6.
- Guerriero S, Alcazar JL, Pascual MA, Ajossa S, Gerado M, Bargellini R, et al. Diagnosis of the most frequent benign ovarian cysts: Is ultrasonography accurate and reproducible? J Womens Health (Larchmt) 2009;18:519-27.
- de Kroon CD, van der Sandt HA, van Houwelingen JC, Jansen FW. Sonographic assessment of non-malignant ovarian cysts: Does sonohistology exist? Hum Reprod 2004;19:2138-43.
- Yasmin S, Yasmin A, Asif M. Clinicohistological pattern of ovarian tumours in Peshawar region. J Ayub Med Coll Abbottabad 2008;20:11-3.
- Choi HJ, Kim SH, Kim SH, Kim HC, Park CM, Lee HJ, et al. Ruptured corpus luteal cysts: CT Findings. Korean J Radiol 2003;4:42-5.
- Ashraf A, Shaikh AS, Ishfaq A, Akram A, Kamal F, Ahmad N. The relative frequency and histopathological patterns of ovarian masses. Biomed 2012;28:98-102.
- Mackenna A, Fabres C, Alam V, Morales V. Clinical managementof functional ovarian cysts: A prospective and randomized study. Hum Reprod 2000;15:2567-9.
- Stenchever MA, Droegemueller W, Herbst AL, Mishell DR Jr. Comprehensive. Gynecology. 4th edition. St. Louis, MO: Mosby; 2006: p. 901-10.
- Barel O, Smorgick N, Pansky M, Schneider D, Halperin R. Clinical and laboratory presentation of haemorrhagic corpus luteum. J Gynaecol Surg 2008;24:11-6.
- Mendal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study of a tertiary hospital of eastern India. J Cancer Res Ther 2011;7:433-7.
- Quirk JT, Natarajan N. Ovarian cancer incidence in the United States, 1992-1999. Gynaecol Oncol 2005;97:519-23.
- Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: A study of 282 cases. J Indian Med Assoc 2002;100:420, 423-4, 447.
- Onyiaorah IV, Anunobi CC, Banjo AA, Fatima AA, Nwankwo KC. Histopathological patterns of ovarian tumours seen in Lagos University Teaching Hospital: A ten year retrospective study. Nig Q J Hosp Med 2011;21:114-8.
Corresponding Author
Dr Doyel Halder
Junior Resident, Department of Pathology, RIMS, Ranchi, Jharkhand, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i5.84
