Abstract
Background: Magnesium is a necessary cofactor of several enzymes involved in glucose metabolism. Insulin resistance or deficiency may exacerbate renal magnesium wasting and hyperglycemia per se induces higher osmotic urinary excretion of magnesium. High prevalence of hypomagnesaemia in T2DM and its chronic complications have been reported in different studies. Hence this study was undertaken to know the incidence of hypomagnesaemia in T2DM patients and its chronic complications.
Material and Methods: In consecutive 100 T2DM patients and 100 control healthy people, serum magnesium was estimated by Calmagite dye Caloric method at one time contact. Opthalmoscopy and 24 hours total urinary protein excretion was measured in T2DM patients. Data were collected and compared by Chi-square test and comparison of mean values were performed by unpaired student ‘t’ test. All statistical data were analysed by SPSS version 16 soft ware for windows.
Results: There was no significant difference in incidence of hypomagnesaemia with age and sex (p>0.05). Hypomagnesaemia was present in 66 (66%) T2DM patients and 8(8%) in healthy people. (p<0.05). Serum magnesium levels were inversely related to FBS, 2hr PPBS and HbA1c levels (p<0.05). Total cholesterol, TG and LDL were inversely related to magnesium level and HDL was positively related (p<0.05). T2DM patients with hypomagnesaemia had higher incidence of proteinuria in 66(99.9%) and diabetic retinopathy 53(80.3%). (p <0.05).
Conclusion: Hypomagnesaemia was common in T2DM patients and its chronic complications.
Keywords: Hypomagnesaemia, T2DM, Glycemic status, Retinopathy, Albuminuria, Dyslipidimia.
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Corresponding Author
Dr Butungeshwar Pradhan
Department of Medicine, VIMSAR, Burla, Sambalpur, Odisha, India
Mobile No.: 9437243697, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v7i5.35
