Abstract
Introduction: Correction of dyslipidemiais important for prevention of atherosclerotic diseases. Limitations of the currently available anti-dyslipidemic drugs prompted us to investigate the anti-dyslipidemic activity of isovaleric acid isolated from Valeriana wallichi.
Methods: The study was conducted on 24 healthy male adult Wistarrats (200-225 gm) divided into four groups of six each. Group I was kept on normal diet (Hindustan Lever Food Pellets). Group II was fedfructose-rich high fat diet (F-HFD). Group III was given F-HFD+isovaleric acid (25 mg/kg of body weight/day), and group IV was given F-HFD+ atorvastatin (10 mg/kg body weight/day). After 30 days, plasma lipids and lipoproteins were measured in all the rats.
Results: Feeding F-HFD resulted in significant dyslipidemia. Isovaleric acid and atorvastatin were equally effective in preventing the F-HFD-induced dyslipidemia.
Conclusions: Further studies are warranted to realize the anti-dyslipidemic potential of isovaleric acid in animals and humans.
Keywords: Dyslipidemia; isovaleric acid; atorvastatin.
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Corresponding Author
Kislay Awasthi
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DOI: https://dx.doi.org/10.18535/jmscr/v7i5.20
