Title: Efficacy and Safety of Azithromycin and Ofloxacin in Uncomplicated Typhoid Fever, in Tertiary Care Hospital at S.K.M.C.H., Muzaffarpur, Bihar
Authors: Dr Ashish Ranjan, Dr Deepak Kumar
DOI: https://dx.doi.org/10.18535/jmscr/v7i5.04
Abstract
Objective: Present study was a Comparative Study and undertaken to know the Efficacy and Safety of Azithromycin and Ofloxacin in Uncomplicated Typhoid Fever.
Materials and Methods: A total of 120 Patients of either sex, aged between 20 and 55 with positive blood culture and Widal test for salmonella typhi along with clinical picture suggestive of typhoid fever were included in the study. All the patients were randomized in two study Groups. Group A included 60 patients, Group B also contains 60 patients. Group A patients received oral ofloxacin 200 mg twice daily for 7 days and Patients in Group B received oral Azithromycin 1 gm on day one and then 500 mg daily from day 2 to day 6. Written consent was taken from all the patients and all the data regarding age, occupation, clinical illness, past history of treatment were noted. All cases were followed up once weekly for a period of 4 weeks. All the cases came for follow up regularly and were examined for fever clearance time, cure rate and recurrence of symptoms of relapse.
Results: Out of 120 patients of typhoid fever 72 patients (60%) were male and 48 patients (40%) were females in the range of 20-55 years. After Ofloxacin treatment in Group A patients, 45(75%) patients showed good or moderate response while a 10 (16.66%) patient showed poor response and 5(8.34%) patients did not responded even after 7 days treatment and was considered treatment failure. Cure rate was found to be 80%. After Azithromycin treatment, all 60 patients (100%) showed good or moderate response and no poor response case was observed.
Conclusion: No significant difference in clinical cure rate was observed in two study groups. No relapse was recorded in the present study in a follow up period of 4 weeks in both study groups.
Kewwords: Enteric fever, Antibiotics, Ofloxacin, Cephalosporins. Azithromycin, Typhoid fever.
