Abstract
Background: Uric acid is a neuroprotective agent. However, its relationship with ischaemic stroke remains controversial. We analyzed the association between serum uric acid and ischemic stroke and clinical outcome.
Aim: 1. To estimate the serum uric acid levels in patients with acute ischemic CVA.
2.To correlate the levels of serum uric acid with the clinical outcome in acute ischemic cva patients
3.To predict the risk of major adverse neurovascular effects following acute ischemic CVA using serum uric acid levels
Materials & Methods: Observational cross sectional study for a duration of 6 months
Observation & Conclusion: Serum uric acid level was found to be increased with patients with acute ischemic stroke and was associated with higher mortality.
Keywords: Uric acid, CVA, predictive factor
References
- World Health Organization. http://www.who.int/ mediacentre/factsheets/fs310/en/Fact sheet N°310. Updated May 2014.
- Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA. 2000;283(18):2404-10.
- Hariklia VD, Apostolos H, Haralambosk. The role of uric acid in stroke. The issue remains unresolved. The Neurologist. 2008;14:238-42.
- Yadav SK, Nepal N, Niroula D. Prevalence of hyperuricemia among people of morang district of nepal. Journal of Nobel Medical College. 2014;13;3(1):16-21.
- Uaratanawong S, Suraamornkul S, Angkeaw S, Uaratanawong R. Prevalence of hyperuricemia in Bangkok population. Clinical rheumatology. 2011;30(7):887-93.
- Berry C, Hamilton CA, Brosnan MJ, Magill FG, Berg GA, McMurray JJ, Dominiczak AF. Investigation into the sources of superoxide in human blood vessels: angiotensin II increases superoxide production in human internal mammary arteries. Circulation. 2000;101(18):2206-12.
- Muir SW, Harrow C, Dawson J, Lees KR, Weir CJ, Sattar N, Walters MR. Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial. Stroke. 2008;39(12):3303-7.
- Chamorro A, Obach V, Cerrera A, Revilla M, Deulofeu R, Aponte JH. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke. 2002;33:1048-52.
- Mazza A, Pessina AC, Pavei A, Scarpa R, Tikhonoff V, Casiglia E. Predictors of stroke mortality in elderly people from the general population the cardiovascular study in the elderly. Eur J Epidemiol. 2001;17:1097-104.
- Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Rheum. 2009;13:885-92. 2
- Heo SH, Lee SH. High levels of serum uric acid are associated with silent brain infarctivn. Journal of the Neurol Scien. 2010;297:6-15. 11. Amaro S, Urra X, Gomez-Choco M. Uric acid levels are relevant in patients with stroke treated with thrombolysis. Stroke. 2011;42:28-32.
- Milionis HJ, Kalantzi KJ, Goudevenos JA, Seferiadis K, Mikhailidis DP, Elisaf MS. Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjects. J Intern Med. 2005;258(5):435-41.
- Shrikrishna R, Suresh DR. Biochemical study of antioxidant profile in acute ischemic stroke. British Journal of Medical Practitioners. 2009;2(1):35-7.
- Weir CJ, Muir SW, Walters MR, Lees KR. Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke. 2003;34(8):1951-6.
- Mozos I, Chiulana C, Goruna C, Costeab S. Serum uric acid in stroke. Annals of West University of Timisoara, Series of Chemistry. 2007;16(2):227-36.
Corresponding Author
Dr Kaveri Kannan
Associate Professor, Department of General Medicine, Kanyakumari Government Medical College, Asaripallam