Abstract
Aim: Cancer cervix is the common malignancy among women globally. The Female population in developing countries is affected inspite of the Screening methods. The patients present in Locally advanced Stage due to Ignorance and Lack of awareness in wide geographic incidence spanning various continents. The aim of the Study is to assess the response with an aggressive treatment with Hyperfractionated Radio therapy and Concurrent cisplatin based chemotherapy in locally advanced Cancer cervix patients.
Patients and Methods: Most Patients belong to the Poor Socio Economic Stratum. Age group 30-60 Years with stage II B and Stage III B. Hyperfractionated Radio therapy 1.2 Gy bid (at 6 hours Interval) for 24 days upto 57.6Gy for 5days a week was given along with Concurrent Chemotherapy with cisplatin and was followed by HDR Brachytherapy 8 Gy in 2#- 1 week apart. The response was assessed after 6 weeks of Completion of treatment
Results: Total no of cases studied were -24 II B cases -14 and IIIB cases – 10. The Overall complete response – 92% and Partial response – 8%.
Conclusion: Invasive Cervical cancer is a Common cause of death in India. In view of the maximal therapy minimal time conceptual model concurrent Chemoradition appears to be ideal treatment to achieve maximal benefit the regimen uses gives better response in advanced stage, younger age group and lower Hemoglobin states at Presentation.
Keywords: Hyperfractionated Radiotherapy, Concurrent chemotherapy, brachytherapy, cancer cervix, cistplatin
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DOI: https://dx.doi.org/10.18535/jmscr/v7i2.163
