Title: Ten years follow up study in Locally advanced Cancer Cervix treated with Hyperfractionated Radiotherapy, Concurrent Chemotherapy and HDR Brachy Therapy
Authors: Dr B. Antoinette Mary Nithiya, Dr A. Anand Praveen Kumar
DOI: https://dx.doi.org/10.18535/jmscr/v7i2.160
Abstract
Aim: Cancer cervix is common malignancy among women globally spanning various continents in the world. The incidence of invasive cervical carcinoma has dropped dramatically due to effective screening techniques. But in India Women present at a locally advanced stage due to lack of awareness and ignorance. The patients are treated and are lost follow up mostly. This study was a continued effort to follow up a group of patient treated in March 2006 to September 2006. Their course of disease and toxicities and their present conditions were analyzed at the end of 10 years.
Patients and Methods: The 24 patients with locally advanced cancer underwent hyper fractionated radiotherapy and concurrent chemotherapy and brachytherapy during the period March 2006 to September 2006. One patient opted out of study at the end of treatment. The rest 23 patients were followed up and condition analyzed at the end of 10 years. Overall survival disease free survival, toxicities and recurrence patterns. Among 13 patients available were analyzed. The various assessments done were detailed history, symptoms clinical examination, USG abdomen, Ct abdomen and pelvis, cystoscopy and Proctoscopy.
Results: Of the 23 patients 7 were lost follow up, 3 expired. Overall survival 13 patients disease free for survival 10 patients, 3 patients had local recurrence and undergone Wertheim’s hysterectomy, 1 patient had skeletal metastasis and undergone RT to spine.
Conclusion: The improvement in the treatment response obtained soon after treatment in our study compared with conventional protocol was sustained even after 10 years which showed a definite improvement in overall survival and disease free survival with acceptable late toxicities. We recommend a randomized study with large number of patients to prove that we achieve in our study are significant.
Keywords: Hyper fractionated Radiotherapy, Concurrent chemotherapy, brachytherapy, cancer cervix, cistplatin
