Abstract
Introduction
Benign adenomyoepithelioma of the breast is a rare tumor characterized by biphasic proliferation of both an inner layer of epithelial cells and a prominent peripheral layer of myoepithelial cells. It was first described by Hamperl[1] in 1970. Benign adenomyoepitheliomas outnumber their malignant counterparts by far. Malignancy may arise either through malignant transformation of 1 of the 2 cellular components or through malignant transformation of both. The difficult differential diagnosis, potential for recurrence and malignant evolution of this lesion merit a careful approach
Clinical Presentation
A 43-year-old woman presented with a swelling in left breast for the past 8 months. On examination, a 3 × 2.5 x 2 cm firm, non-tender, and mobile mass was palpated. Fine needle aspiration cytology of the mass showed clusters and sheets of ductal epithelial cells with apocrine metaplasia and hyperplasia along with clusters of myoepithelial/ stromal cells in background of eosinophilic fluid and cyst macrophages (figure1,2). Hence a diagnosis of a Fibrocystic disease was made on cytological evaluation. Subsequently the mass was excised in toto and sent for histopathological examination.
References
- Hamperl H: The myothelia (myoepithelial cells): normal state; regressive changes; hyperplasia; tumors. Curr TopPathol; 1970; 53: 161–220.
- Kiaer H, Nielsen B, Paulsen S, Sorensen I, Dyreborg U, Blichert-Toft M: Adenomyoepithelial adenosis and lowgrade malignant adenomyoepithelioma of the breast. Virchows Arch A Pathol Anat Histopathol; 1984; 405: 55-67.
- Choi JS, Bae JY, Jung WH: Adenomyoepithelioma of the breast—its diagnostic problems and histogenesis. Yonsei Med J; 1996; 37: 284-289
- Maruya S1, Kies MS, Williams M, Myers JN, Weber RS, Batsakis JG, El-Naggar AK. Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications.
- Berna J, Arcus L, Ballester A, Bas A:Adenomyoepithelioma of the breast in a male [letter]. AJR Am J Roentgenol; 1997; 169: 917–918.
- Ahmed AA, Heller DS: Malignant Adenomyoepithelioma of the Breast With Malignant Proliferation of Epithelial and Myoepithelial Elements A Case Report and Review of the Literature. Arch Pathol Lab Med; 2000; 124: 632–636.
- Gatti G, Viale G, Simsek S, Zurrida S, Intra M, Caldarella P et al: Adenomyoepithelioma of the breast, presenting as a cancer. Tumori; 2004; 90: 337-339.
- Gill TS, Clarke D, Douglas-Jones AG, Sweetland HM, Mansel RE: Adenomyoepithelioma of the breast: a diagnostic dilemma. Eur J Surg Oncol; 2000; 26: 316-318.
- Tsuda H, Takarebe T, Hasegawa F, Fukutomi T,Hirohashi S: Large central acellular zones indicating myoepithelial tumor differentiation in high grade invasive ductal carcinomas as markers of predispositions to lung and brain metastases. Am J Surg Pathol; 2000; 24: 197-202.
- Tamura G, Monma N, Suzuki V, Satodate R, Abe H: Adenomyoepithelioma (myoepithelioma) of the breast in amale. Hum Pathol; 1993; 24: 678–681.
Corresponding Author
A Haretha
Postgraduate, Trichy SRM Medical College, Hospital & Research Center, Trichy
DOI: https://dx.doi.org/10.18535/jmscr/v7i2.132
